Pre-B cell acute lymphoblastic leukemia with bulk extramedullary disease and chromosome 22 (EWSR1) rearrangement masquerading as Ewing's sarcoma

Jakovljević, Gordana; Nakić, Melita; Rogošić, Srđan; Kardum-Skelin, Ika; Mrsić-Davidović, Sanja; Zadro, Renata; Krušlin, Božo

doi:10.1002/pbc.22365

Pregled bibliografske jedinice broj: 461446

Pre-B cell acute lymphoblastic leukemia with bulk extramedullary disease and chromosome 22 (EWSR1) rearrangement masquerading as Ewing's sarcoma

Jakovljević, Gordana; Nakić, Melita; Rogošić, Srđan; Kardum-Skelin, Ika; Mrsić-Davidović, Sanja; Zadro, Renata; Krušlin, Božo

Pre-B cell acute lymphoblastic leukemia with bulk extramedullary disease and chromosome 22 (EWSR1) rearrangement masquerading as Ewing's sarcoma // Pediatric blood & cancer, 54 (2010), 4; 606-609 doi:10.1002/pbc.22365 (recenziran, članak, stručni)

CROSBI ID: 461446 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Pre-B cell acute lymphoblastic leukemia with bulk extramedullary disease and chromosome 22 (EWSR1) rearrangement masquerading as Ewing's sarcoma

Autori
Jakovljević, Gordana ; Nakić, Melita ; Rogošić, Srđan ; Kardum-Skelin, Ika ; Mrsić-Davidović, Sanja ; Zadro, Renata ; Krušlin, Božo

Izvornik
Pediatric blood & cancer (1545-5009) 54 (2010), 4; 606-609

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, stručni

Ključne riječi
lymphoblastic leukemia; chromosome 22; Ewing sarcoma

Sažetak
We report a 2-year-old female with a subcutaneous tumor who was initially misdiagnosed as suffering from Ewing sarcoma with a positive EWSR1 rearrangement and EWS/FLI1 transcript. After finding lymphoblasts in peripheral blood, the diagnosis of acute lymphoblastic leukemia was established. This necessitated further analysis of the subcutaneous tumor. The tissue was positive for immature B-cell markers and an immunoglobulin heavy chain gene rearrangement, which confirmed the final diagnosis of common type acute lymphoblastic leukemia with bulk extramedullary disease. The patient was treated with chemotherapy and was in remission 30 months after the diagnosis.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA

Projekti:
108-1081870-1884 - Razvojna neuropatologija genetskih malformacija moždane kore čovjeka (Krušlin, Božo, MZOS ) ( CroRIS)
108-1081873-1893 - Prognostički faktori, dijagnostika i terapija hemoblastoza (Jakšić, Branimir, MZOS ) ( CroRIS)
134-0000000-3381 - Promjene bubrežne arterije u bolesnika s karcinomom bubrega (Čupić, Hrvoje, MZOS ) ( CroRIS)
198-1980955-0953 - Imunobiologija kronične B-limfocitne leukemije i mikrookoliš (Jakšić, Ozren, MZOS ) ( CroRIS)

Ustanove:
Klinička bolnica "Merkur",
Klinika za dječje bolesti Medicinskog fakulteta,
Medicinski fakultet, Zagreb,
KBC "Sestre Milosrdnice",
Klinički bolnički centar Zagreb

Profili:

Renata Zadro (autor)