Naslov
Expression of cytokine genes in peripheral blood mononuclear cells of patients undergoing postmastectomy radiotherapy

Autori
Juretić, Antonio ; Šamija, Mirko ; Spagnoli, C, Giulio ; Krajina, Zdenko ; Živković, Mirko ; Herceg, Tonko ; Šobat, Hrvoje ; Bistrović, Matija ; Eljuga, Damir ; Turić, Marko ; Zuber, Marcus ; Heberer, Michael

Izvornik
Croatian medical journal (0353-9504) 38 (1997), 4; 327-331

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
RT-PCR ; cytokine genes

Sažetak
Methods. Freshly isolated PBMC collected from fifteen patients before, during, and at the end of irradiation treatment were studied by a reverse transcription-polymerase chain reaction (RT-PCR). Results. IL-1a, IL-2, IL-5, and INFg gene transcripts were rarely or never detectable, whereas IL-10 expression was often observed in the pre-treatment samples. Conclusion. These data, obtained by taking advantage of a sensitive technique closely reflecting in vivo events, suggest that systemic monocyte activation could take place in therapeutically irradiated patients.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA