Naslov
Impact of pre-morbid depression on health-related quality of life in non-demented Parkinson's disease patients

Autori
Klepac, Nataša ; Hajnšek, Sanja ; Trkulja, Vladimir

Izvornik
Parkinsonism & related disorders (1353-8020) 16 (2010), 1; 21-27

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Parkinson's disease; depression; quality of life; mMotor symptoms; non-motor symptoms

Sažetak
In order to investigate contribution of depression that existed before the onset of typical motor symtomss (pre-PD depression), idiopathic non-demented non-psychotic patients with (n=32) and without (n=120)a history of pre-PD depression, free of relevant comorbidity, calliper matched for age, education and disease duration wewr evaluated for motor and non-motor disease aspects and HrQoL (Parkinson' Disease Questionnaire 39, PDQ-39). History of pre-PD depression was independently associated with higher actual levels of depression and anxiety, poorer sleep quality and mental set shifting, which all contributed to poorer Hr-QoL. Mediation analysis demonstrated significant indirect effects (mediated through the effects on mood/emotion/sleep and/or cognition) of pre-PD depression on PDQ summary index and subscales, but also direct (non-mediated) effects on emotional well-being and body discomfort subscales independent of the sociodemographic, motor/non-motor disease or treatment-related characteristics. Data indicate that for a given level of motor/non-motor PD symptoms severity, history of pre-PD depression contributes to poorer Hr-QoL.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA