Naslov
Frequency of Factor II G20210A, Factor V Leiden, MTHFR C677T and PAI-1 5G/4G Polymorphism in Patients with Venous Thromboembolism: Croatian Case Control Study

Autori
Alfirević, Zrinka ; Šimundić, Ana-Maria ; Nikolac, Nora ; Sobočan, Nikola ; Alfirević, Igor ; Štefanović, Mario ; Vučićević, Željko ; Topić ; Elizabeta.

Izvornik
Biochemia medica : časopis hrvatskoga društva medicinskih biokemičara (1330-0962) 20 (2010), 2; 229-235

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Thrombophilia; coagulation disorders; polymorphism; FV Leiden; PAI-1; MTHFR

Sažetak
Introduction: Venous thromboembolic disease is one of the leading causes of morbidity and mortality in the developed world. Identification of hereditary factors of thrombophilia is contributing to a better understanding of the etiology and prevention of the disease. The aim of this study was to assess the prevalence of factor II G20210A, factor V Leiden, MTHFR C677T and PAI-1 5G/4G polymorphisms in healthy Croatian subjects and in patients with thromboembolism. Materials and methods: This prospective study included 106 healthy subjects and 100 thromboembolic patients who were consecutively admitted to the Intensive Care Unit, University Hospital "Sestre milosrdnice". Results: Heterozygotes for Factor V Leiden polymorphism were more frequent in the group of patients with the thromboembolic disease (16%) than in the control healthy subjects (2.9%), with OR 6.413 (1.807 - 22.758 ; P = 0.004). Allele and genotype frequencies of other studied polymorphisms did not differ between cases and controls. Conclusion: This study confirmed the association of factor V Leiden polymorphism with the development of the thromboembolic disease in Croatian population.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA