Naslov
The association between functional catechol-o-methyltransferase polymorphism and smoking in male and female schizophrenic patients and healthy subjects

Autori
Pivac, Nela ; Nedić, Gordana ; Nikolac, Matea, Borovečki, Fran ; Šagud, Marina ; Hajnšek, Sanja ; Vuksan Čusa, Bjanka ; Mihaljević Peleš, Alma ; Muck-Šeler, Dorotea

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Zbornik sažetaka 2. hrvatskog kongresa o nuspojavama psihofarmaka s međunarodnim sudjelovanjem / Uzun, Suzana - Zagreb : Agencija za lijekove i medicinske proizvode, 2010, 61-62

Skup
Hrvatski kongres o nuspojavama psihofarmaka s međunarodnim sudjelovanjem (2 ; 2010)

Mjesto i datum
Rovinj, Hrvatska, 11.03.2010. - 14.03.2010

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Domaća recenzija

Ključne riječi
catechol-O-methyltransferase; smoking; COMT Val158Met polymorphism; healthy subjects; schizophrenic patients

Sažetak
Tobacco smoking is a global health problem with far reaching consequences. Substances from tobacco smoke may affect brain functions via several neurotransmitters. Tobacco smoking is associated with various somatic and neuro-psychiatric disorders, altered behaviors and might represent a risk factor for suicide. A myriad of factors including environmental, biological and genetic factors are responsible for smoking behavior, smoking initiation, regular tobacco use, and nicotine dependence. The studies of allelic variations in genes involved in acetylcholine and dopamine pathways are aimed at finding a possible association between particular candidate genes and smoking. Catechol-O-methyltransferase (COMT) is an enzyme involved in degradation of dopamine, epinephrine, norepinephrine and is considered a major risk factor for smoking. The most frequently studied variation in the COMT gene, COMT Val158Met polymorphism, is a SNP that involves a substitution of valine (Val) with methionine (Met). There are a lot of conflicting and inconclusive findings regarding smoking status and COMT variants. The present study evaluated the possible association between smoking and COMT Val158Met polymorphism in male and female schizophrenic patients (diagosis made according to SCID and DSM-IV criteria) and healthy subjects. All subjects were subdivided into smokers (subjects smoking  10 cigarettes per day) and nonsmokers (subjects who never smoked in their life). We found significant (2 test) differences in the Met/Met, Met/Val or Val/Val genotype frequency between male schizophrenic smokers and nonsmokers, and between healthy male smokers and nonsmokers, due to the higher frequency of Val/Val homozygotes in smokers. COMT variants did not differ significantly within female healthy or schizophrenic smokers and nonsmokers. There were no significant gender related differences in the frequency of the COMT variants between male and female smokers and nonsmokers. The significant association between COMT variants and smoking suggested that Val/Val genotype might be a risk factor for smoking.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti, Dentalna medicina

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