Naslov
Inflammation and Colon Cancer

Autori
Terzić, Janoš ; Grivennikov, Sergei ; Karin, Eliad ; Karin, Michael

Izvornik
Gastroenterology (New York, N.Y. 1943) (0016-5085) 138 (2010), 6; 2101-2114e5

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
colon cancer; inflammation; immunity; cytokines

Sažetak
The connection between inflammation and tumorigenesis is well-established and in the last decade has received a great deal of supporting evidence from genetic, pharmacological, and epidemiological data. Inflammatory bowel disease is an important risk factor for the development of colon cancer. Inflammation is also likely to be involved with other forms of sporadic as well as heritable colon cancer. The molecular mechanisms by which inflammation promotes cancer development are still being uncovered and could differ between colitis-associated and other forms of colorectal cancer. Recent work has elucidated the role of distinct immune cells, cytokines, and other immune mediators in virtually all steps of colon tumorigenesis, including initiation, promotion, progression, and metastasis. These mechanisms, as well as new approaches to prevention and therapy, are discussed in this review.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti

Napomena
Colon Cancer : An Update and Future Directions.

POVEZANOST RADA