ࡱ> {}zU bjbj 4H+ 8O$su-oo```|,~,~,~,~,~,~,$/1j,`````,/-***`|,*`|,***^5@d *h,E-0u-*2*(2**&2*``*`````,,*```u-````2````````` : Feed additives-potent immunomodulators? `peranda Marcela1, Mislav idara1, Tomislav `peranda2, Matija Domainovi1, Hrvoje Valpoti3, Zvonko Antunovi1 1 Faculty of Agriculture University of J. J. Strossmayer in Osijek 2Medical-Intertrade, Sveta Nedelja 3Veterinary faculty University of Zagreb Abstract The animal health is prerequisite for the quality and safety of foods for human consumption. Therefore we use feed additives and research active components for promoting health in animals (especially reinforcing the immune system). Ninty two commercial crossbred piglets weaned at 28th day and attended until 63rd day of life were divided into four groups of twenty three piglets. The first, control group had no supplementation in feed. The second and the third experimental group were added 0.2% Bio-Mos and 0.2% Progut preparation in the feed mixture, during the whole experimental period. Piglets from the fourth experimental group was treated with 10 ml orally given copolymer of polyoxyethylene and polyoxypropylene (POE-POP, USA patent No. 5.234.683/1993) on the weaning day (0 day). Body weight was controlled at the beginning of the trial, 21st and 35th day after weaning day and blood samples were taken from the animals in order to determine haematological values. At the end of the trial, number of leucocytes was significantly (P<0.05) higher in Bio-Mos group in relation to the control one. The highest share of lymphocytes had piglets with addition POE-POP, but not significantly. Copolymer acted like strong growth promotor and all feed additives protected from the conditional diseases. Key words: pig, feed additives, Mannanoligosaccharides, copolymers, heamatological parameters Introduction Last twenty years concepts in animal nutrition have been changing. Scientist all areas looking for the optimal nutrition which must be efficient in production, but also to promote health and protect against diseases. The animal health is prerequisite for the quality and safety of foods for human consumption. Therefore we use feed additives and research active components for promoting health in animals (especially reinforcing the immune system). What we can use as a feed additives? Feed additives are products used in animal nutrition for purposes of improving the quality of feed or to improve the animals performance and health, e.g. providing enhanced digestibility of the feed materials. It is of the grate importance, especially for the weaning piglets. Weaning is the grate challange in the modern swine production. That physiological event takes place early in the piglets life (from 21st to 28th day of life), and could be the trigger for diarrhea inccurence which slow down growing and could cause the death of the animals. Last decades scientist are looking for alternative feed additives which can block patogen bacteria whithout antibiotic usage. The aim of this paper is to confirm how different feed additives influence on growth and haematological indicators, especially with regard on immunohaematological status of weaned piglets. Therefore we use three experimental groups: mannanoligosacharides from the products Bio-Mos, and Progut and copolymers polioxyethilene (POE) and polyoxipropylene (POP). Mannanoligosaccharides (Bio-Mos), derived from mannans on yeast cell surfaces, act as high-affinity ligands and as a competitive binding site for the bacteria with mannose-specific fimbriae (Fairchild et al., 2001). Is well known that oligosaccarides improved growth and feed efficiency of weaned pigs (Burkey et al., 2004) associated with bacterial adhesions (Fairchild et al., 2001) and stimulated immunity in fish (Staykov et al., 2005) and turkeys (Cetin et al, 2005). Additional methods processing long polysacharides chains, enchanes their activities. Hydrolyzed whole yeast (Progut) is a mixture of mannans, -glucans, nucleotides and peptides. It's hydrolyzed from inactivated yeast but unlike cell wall products it also contains the extract part of the yeast. Synthetic compounds termed nonionic block copolymers polioxyethilene (POE) and polyoxipropylene (POP) used like adjuvant in parenteral immunization. They act by adherence to lipids, promoting the retention of the protein antigen in local tissue and facilitating the uptake of the antigen by antigen presenting cells (Hunter et al. 1994). Now, we wanted to see how it works alone, without vaccine. Materials and methods Animals used in this study were maintained in facilities approved by the Croatian Association for Accreditation of Laboratory Animal Care, and in accordance with current regulation and standards issued by the Croatian Ministry of Agriculture. Ninty two commercial crossbred piglets (Swedish LandraceX Large White X Pietrein), progeny of eleven litters and three boars, weaned at 28th day and attended until 63rd day of life were used in the trial. Piglets were divided into four groups of twenty three piglets. Piglets were housed in isolation pens at 21 20 C and received a commercial weaner diet without antibiotics and had an unlimited acces to water. Piglets from all groups were fed on fodder mixture for weaned piglets containing 22% crude protein and 13.84 MJ ME/kg until 21st day after weaning (the first nutrition period, 1st NP; from 0 to 21st day) and on fodder mixture for growing pigs with 19% crude protein and 13.74 MJ ME/kg until they were 63 days old (the second nutrition period, 2nd NP; from 22nd to 35th day). The second and the third experimental group were added 0.2% Bio-Mos and 0.2% Progut preparation in the feed mixture, during the whole experimental period. The fourth experimental group was treated with 10 ml orally given copolymer of polyoxyethylene and polyoxypropylene (POE-POP, USA patent No. 5.234.683/1993) on the weaning day (0 day). Body weight was controlled at the beginning of the trial, 21st and 35th day after weaning day. In the same time blood samples were taken from the animals in order to determine haematological values. Five millilitre samples were obtained from the v. Cavae cranialis using a Venoject(R) vacutainer into a test tube containing an anticoagulant (EDTA). The number of erythrocytes, leukocytes, levels of haemoglobin and haematocrit were established using the Serono Backer 9120 automatic counter. Blood smears were prepared and stained according to Pappenheim and investigated under a microscope in order to determine the differential blood count. The relative ratio of individual cells of leukocytes is given in percentages in relation to their total number. The data were analyzed using the general linear model procedure of the StatSoft, Inc. Statistica (2008). Results and discussion Tables 1, 2, and 3 presented complete blood count, excluding number of leucocytes and differetial white blood, because we use them like immunohaematological parameters. Piglets all groups on the beginning of the trial had similar number of erytrocytes and erythrocyte constants (MCV, MCH, MCHC, RDW), haemoglobine and haematocrit (Table 1). Table 1. Haematological indicators of weaned piglets all groups at the begining of the trial (day 0). Control  EMBED Equation.DSMT4 sdBioMos  EMBED Equation.DSMT4 sdProgut  EMBED Equation.DSMT4 sdPOE-POP  EMBED Equation.DSMT4 sdErythrocytes x1012L-15,331,264,990,345,330,585,170,43Haemoglobin, gL-194,7131,4487,295,9194,8612,08885,83Haematocrit, %30,2911,3826,712,2929,295,4732,149,49MCV fl55,57a6,753,711,554,434,7249,43b14,3MCH pg17,291,717,290,4917,570,9817,140,69MCHC gL-1316,4316,5324,438,18323,2920,54312,1410,73RDW25,14a1,8624,86a3,3924,573,0527,57b1,27a,b=P<0.05; There were no differences in the same parameters between the experimental groups on the 21st day of the trial (Table 2). But, at the end of the trial, significantly (P<0.05) higher number of erytrocytes had piglets with Bio-Mos supplementation in relation to the control group (Table 3). Table 2. Haematological indicators of the weaned piglets with addition different feed additives 21st day of the trial Control  EMBED Equation.DSMT4 sdBioMos  EMBED Equation.DSMT4 sdProgut  EMBED Equation.DSMT4 sdPOE-POP  EMBED Equation.DSMT4 sdErythroc x1012L-15,150,574,960,214,890,85,560,65Haemoglobin, gL-195,1713,14895,3288,7110,8698,4311,18Haematocrit, %28,674,9726,291,825,864,1829,863,89MCV fl554,152,862,8553,142,6753,291,25MCH pg18,50,55180,5818,290,7617,710,95MCHC gL-1335,3318,733914,8344,7117,9333110,86RDW25,672,7325,290,9523,711,8251,29 Table 3. Haematological indicators of the weaned piglets with addition different feed additives 35th day of the trial Control  EMBED Equation.DSMT4 sdBioMos  EMBED Equation.DSMT4 sdProgut  EMBED Equation.DSMT4 sd  EMBED Equation.DSMT4 POE-POP  EMBED Equation.DSMT4 sdErythrocy x1012L-15,32a0,946,17b0,735,760,556,010,45Haemoglobin, gL-199,5714,27113,4316,07105,579,05108,436,27Haematocrit, %29,715,0633,714,7532,432,9933,142,19MCV fl563,3254,862,4856,712,2955,431,4MCH pg18,861,2118,431,7218,140,9180,58MCHC gL-1336,2913,05336,2923,02323,576,73324,435,44RDW25,862,6124,14a2,0423,14b1,5724,432,23a,b=P<0.05; Haematological test revealed that total white blood cells did not differ between groups 21st day of the trial, although in the group with POE-POP supplementation was the highest (Graf 1). At the end of the trial, number of leucocytes was significantly (P<0.05) higher in Bio-Mos group in relation to the control one.  Graf 1. Number of white blood cells (x109L-1) in the blood of weaned piglets with addition different feed additives Share of the neutrophyls was significantly lower in the control group 21st day of the trial in relation to the experimental groups (Graf 2), while at the end of the trial piglets all groups had about 45% share of neutrophyls which can we consider referent according to Evans (2000). However, share of lymphocytes was higher in the control group of piglets in relation with POE-POP (P<0.05) and Bio-Mos and Progut (P<0.01), but only 21st day of the trial. At the end of the experiment the higher share of lymphocytes had piglets with addition POE-POP. This is in agreement with ver et al. (1996) who found copolymers stimulatory effect on T and B lymphocytes, and natural killer cells in the lymphatic tissue of the gastrointestinal tract. But lymphocytes from the group with mannans were higher than in the control group, which also suggest that they had immunostimulatory effect, which confirmed peranda et al (2008) with proof of higher CD4 and CD8 lymphocyte subsets in the peripheral blood of the weaned piglets and Cetin et al (2005) who found MOS elevate IgG and IgM levels in turkey. Neutrophils are important component of innate immunity involved in antibacterial defense. An increase in the number of neutrophils indicates either an infection or an influence of stress, exercise or glucocorticoid hormones (McGlone et al, 1983) or may be indicator of the stressfulness of the handling experience (Salak-Johnson and McGlone, 2007). Until the experimental groups showed normal leucogram, in the piglets' blood from the control group on the 21st day of the trial, neutrophile:lymphocyte reversal occurs, resulting in the predominant neutrophils leukograms that is typical for viral infections (Evans, 2000). Piglets from the control group had diarrhea (data not shown) during the experimental period and needed individualy medication. It is important to know that commercial farm are positive of porcine reproductive and respiratory syndrome (PRRS) an rotaviruses.  *P<0.05; **P<0.01 Graf 2. Share of neutrophils (%) in the blood of weaned piglets with addition different feed additives  Graf 3. Share of lymphocytes (%) in the blood of weaned piglets with addition different feed additives  Graf 4. Mean body weight of weaned piglets with addition different feed additives during 35 days of the trial The heaviest body mass had piglets with POE-POP supplementation during whole experimental period, while piglets from the other groups had similar body mass as a control group. Thaxton et al. (1992) reported also that copolymer is and effective growth promoter in broilers, primary because of the ability to act as adjuvant to immune response. But, there is no enough data about in vivo acting copolymers on swine growing. Kabanov et al (2002) found that relatively high concentrations of the block copolymer were delivered to the organs, where it remained accumulated for the long period. That is the reason how it works so strong on the growing during 35 days on a one time basis. Mannans did not show strong effect on the growing. Miguel et al. (2004) showed that dietary inclusion of the mannanoligosaccharides is the most effective immediately after weaning, our data show scarcely grater body weight in relation to the control piglets. It is known for a long time that yeast cultures have mainly been associated with yeast metabolites (Girard, 1996), now is clear that some of the positive effects of yeast in monogastrics might be associated with the yeast cell wall. Mannans can block attachment of ceratain bacteria to the intestinal wall and that is probably the main mechanism of positive effect that preparation on the health of the piglets. Van der Peet-Schwering et al (2007) determined improved average daily gain (P=0.06) for piglets that were fed the supplemented diets with yeast culture and modified yeast culture+ cell wall product. Their effect is dependent on dose, so Li et al (2006) found that pigs supplemented with 100 and 200 ppm of -glucan had lower average daily gain than pigs supplemented with 50 ppm. Very high doses lead to increasing syntesis of proinflammatory IL-1 which is associated with decreased feed intake and growth performance (Klasing et al, 1987). Conclusion Comparing different feed additives for weaned piglets we can conclude that POE-POP is the most powerful growth promotor. Live yeast culture preapared by different production methods stimulated immune system. Bio-Mos upraised significantly number of WBC count and piglets with feed supplementation did not show signs of virus infection, like piglets from the control group (without any feed additives). Piglets with POE-POP addition did not have diarrhoea during the whole experimental period. Acknowledgments This project was supported financially by grant no. 0793448-3438 founded by the Ministry of Science, Education and Sports of Croatia. References Burkey T. E., Dritz S. S., Nietfeld J. C., Johnson B. J., Minton J. E: (2004): Effect of dietary mannanoligosaccharide and sodium chlorate on the growth performance, acute-phase response, and bacterial shedding of weaned pigs challenged with Salmonella entericaserotype Typhimurium. J Anim Sci 82, 397-404 Cetin N., Gcl B. K., Cetin E. (2005): The effect of probiotic and mannanoligosaccharide on some haematological and immunological parameters in turkeys. J Vet Med A Physiol Pathol Clin Med, 52(6): 263-267. Evans E. (2000): Interpretation of porcine leukocyte responses. In: Feldman B. F., J. G. Zinkl, N. C. Jain: Schalm's Veterinary Hematology, 168: 1089-1095. Lippincott Williams & Wilkins, Philadelphia, Baltimore, New York, London, Buenos Aires, Hong Kong, Sidney, Tokyo. Fairchild, A. S., J. L. Grimes, F. T. Jones, M. J. Wineland, F. W. Edens, and A. E. Sefton (2001): Effects of hen age, Bio-Mos, and Flavomycin on poult susceptibility to oral Escherichia coli challenge. Poultry Science 80:562-571 Girard, I. (1996): Characterisation of stimulatory activities from Saccharomyces cerevisiae on the growth and activities of ruminal bacteria. Dissertation, University of Kentucky, Leeington, KY. Hunter, R. L., McNicholl J., Lal, A. A., (1994): Mechanisms of action of nonionic block copolymer adjuvants. AIDS Res Hum Retroviruses 10 (2):95-98. Kabanov A. V., Batrakova E. V., Alakhov V. Y. (2002): Pluronic block copolymers as novel polymer therapeutics for drug and gene delivery. Journal of Control Release 82, 189-212. Klasing, K. C., Laurin D. E., Peng R. K., Fry D. M: (1987): Immnologically mediated growth depression in chicks: Influence of feed intake, corticosterone and interleukin-1. J Nutr 117: 1629-1637. Li, J., Li, D.F., Xing, J.J., Cheng, Z.B., Lai, C.H., (2006): Effects of  glucan extracted from Saccharomyces cerevisiae on growth performance, and immunological and somatotropic responses of pigs challenged with Escherichia coli lipopoysaccharide, J. Anim. Sci, 84, 2374-2381. Miguel, J.C., Rodriguez-Zas, S.L., Pettigrew, J.E., (2004): Efficacy of a mannan oligosaccharide (Bio-Mos) for improving nursery pig performances, Jou Swine Health Prod ,12(6), 296-307. McGlone, J.J., Salaj, J.L., Lumpkin, E.A., Nicholson, R.I., Gibson, M., Norman, R.L., (1983): Shipping stress and social status effects on pig performance, plasma cortisol, natural killer cell activity, and leukocyte numbers, J. Anim. Sci., 71, 888-890. Staykov, Y. Denev, S. Spring, P., (2005a): The effects of mannan oligosaccharide (Bio-Mos) on the growth rate and immune function of rainbow trout (Salmo gairdneri irideus G.) grown in net cages. In: Lessons from the past to optimise the future, Ed. by B Howell and R Flos. European Aquaculture Society, Special Publication No 35, June 2005, p 427-428. Salak-Johnson, J.L., McGlone J.J., (2007): Making sense of apparently conflicting data: stress and immunity in swine and cattle, J. Animal Sci., 85, E81-E88. StatSoft, Inc. (2008): STATISTICA (data analysis software system), version 8.0. 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(2008): Hydrolyzed brewery yeast product (Progut) like immunomodulator in weaned piglets. Archiva Zootechnica 11(3), 52-60 `ver, L., Trutin-Ostovi. K., }ub i, D., Casey, A. T., Dean-Nistrom. E. A., Valpoti I., (1996): Porcine gut T, B, and null/ TCR+ cell quantification in the protective immunity to fimbria/toxin antigens of Escherichia col@FHMosu飡{l`lQIEIhBjhBUh $h{CJOJQJaJhI'KCJOJQJaJhI'KhI'KCJOJQJaJ%h $CJOJQJaJmH nH sH u%hCCJOJQJaJmH nH sH uU.h6hC6CJOJQJaJmH nH sH u.h6hCCJH*OJQJaJmH nH sH u+h6hCJOJQJaJmH nH sH u+h6hCCJOJQJaJmH nH sH ui. Periodicum Biologorum, Vol 98 (4): 473-478. Thaxton, J. P., Chamblee, T. N Thompson, J. R., Schultz, C. D, (1992): Growth promotion in broilers by copolymer CRL87-61. Appl. Poultry Res 1: 373-381. Van der Peet-Schwering, C.M.C., Jansman, A.J.M., Smidt, H., Yoon, I., (2007) Effects of yeast culture on performance, gut integrity and blood cell composition of weanling pigs, J. Anim. Sci, 85, 3099-3109.      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