Naslov
In vitro model of bone regeneration with bioactive glass and lipid peroxidation

Autori
Mrakovčić, Lidija ; Cindrić, Marina ; Žarković, Neven ; Borović Šunjic, Suzana ; Moguš Milanković, Andrea ; Wildburger, Renate

Izvornik
Clinical and experimental medical journal (2060-6249) 4 (2010), 1; 73-78

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
bone regeneration ; bioactive glass ; 4-hydroxynonenal

Sažetak
Tissue regeneration is complex biological process of vital importance since it allows renewal of damaged cells and organs. Healing of long bones and large joints is often extended or incomplete primarily in elderly people or in polytraumatized patients. Various attempts are done to solve this severe medical and social problem by development of novel bioactive materials, among which bioactive glass is the most attractive because of its osteoconductive and osteostimulative properties. Lipid peroxidation was defined as important parameter of systematic stress response in patients with traumatic brain injuries and bone fractures. The major bioactive marker and final product of lipid peroxidation, 4-hydroxynonenal (HNE) is particularly interesting biomolecule because it regulates differentiation, proliferation and apoptosis of cells and might therefore play important role regulating regeneration of damaged tissue such as bone. Therefore, in the present study we investigated the concept of using bioactive glass functionalised with HNE as an in vitro model of bone regeneration.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Temeljne medicinske znanosti

POVEZANOST RADA