Naslov
Thiopurine S-methyltransferase pharmacogenetics: Genotype to phenotype correlation in the Slovenian population

Autori
Milek, Miha ; Murn, Jernej ; Jakšić, Željko ; Lukac-Bajlo, Jana ; Jazbec, Janez, Mlinarič-Raščan, Irena

Izvornik
Pharmacology (0031-7012) 77 (2006); 105-114

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
genetic polymorphism; Slovenian population; thiopurine S-methyltransferase; pharmacogenetics; ACTH; CCK. cortisol; HPA axis; itopride; motilin; somatostatin; stress

Sažetak
Itopride hydrochloride (itopride), a gastrokinetic drug, has recently been evaluated for its clinical usefulness in functional dyspepsia. We investigated effects of itopride on human plasma gastrin-, somatostatin-, motilin-, and cholecystokinin (CCK)-like immunoreactive substances (IS) ; adrenocorticotropic hormone (ACTH)-immunoreactive substances (IS), and cortisol under stress conditions in healthy subjects. A single administration of itopride caused significant increases in plasma somatostatin- and motilin-IS levels compared to placebo. Itopride significantly decreased plasma CCK-IS, and suppressed the ACTH-IS level compared to placebo. We hypothesize that itopride may have an accelerating gastric emptying effect, and a modulatory effect on the hypothalamo-pituitary-adrenal axis and autonomic nervous functions. These effects might be beneficial in stress-related diseases, suggesting that itopride has clinicopharmacological activities.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Farmacija

POVEZANOST RADA