Naslov
Serum vitamin D level and bone mineral density in premenopausal and postmenopausal women in Croatia

Autori
Bobinac, Dragica ; Starčević Klasan, Gordana ; Cvijanović, Olga ; Fužinac, Arijana ; Arbanas, Juraj ; Zoričić, Sanja

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Delegate handbook / - Sydney, 2009, 106-106

Skup
2nd Joint Meeting International Bone & Mineral Society and Australian & New Zealand Bone & Mineral Society

Mjesto i datum
Sydney, Australija, 21.03.2009. - 25.03.2009

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
vitamin D; bone mineral density; premenopausal women; postmenopausal women

Sažetak
Aim: To evaluate the vitamin D status and bone mineral density (BMD) of premenopausal and postmenopausal women in Croatia and to assess the probable correlation of vitamin D serum level with BMD. Material and methods: We conducted a cross-sectional observational study of 790 women. The age range was 44-78 years. Serum 25(OH)vitamin D was assayed in each patient. Spine and proximal femur BMD were measured by dual energy X-ray absorptiometry (DEXA). Women were divided into subgroups. The first group consisted of 70 younger women with regular menstrual status, second group was consisted of 240 postmenopausal women within 5 years since menopausa, and the third group was consisted of 480 postmenopausal women with more than 5 years since menopausa. Results: Based on data in the literature, we used four 25(OH)D cutoffs to define vitamin D deficiency: 30, 50, 75, and more than 75 nmol/L. Vitamin D serum level was found in 8.02%, 24.1%, 30.3%, and 36.7% with 30, 50, 75, and more than 75 nmol/L cutoffs, respectively. The mean serum 25(OH)D level was 60.81+/-26.1 nmol/L, 67.25 +/- 21.4 nmol/L, and 68.86 +/- 18.1 nmol/l with the first to the third group of women, respectively. 25(OH)D serum level slightly increases with age in Croatian women but not statistically significant. Measurement of BMD by DEXA have shown that osteopenia or osteoporosis are even present in younger women with regular menstrual status. Such women have lower than 30 nmol/L of serum vitamin D level. The number of women who has osteopenia or osteoporosis is increased with age. In these groups serum vitamin D level is in negative correlation with BMD. In the third group the prevalence of osteoporosis is the highest. The mean characteristics of the first group of women is that deficiency of vitamin D correlates with osteopenia or osteoporosis. Conclusion: Vitamin D deficiency is common among premenopausal and postmenopausal women with osteopenia or osteoporosis in Croatia (T-score less than or equal to -2.5). We found correlation among low serum vitamin D level and osteopenia or osteoporosis in younger women with regular menstrual status.

Izvorni jezik
Engleski

POVEZANOST RADA