Naslov
Metabolic bone disease in after renal transplantation in patients with Balkan endemic nephropathy
(MEetabolic bone disease in after renal transplantation in patients with Balkan endemic nephropathy)

Autori
Bašić-Jukić, Nikolina ; Šmalcelj, Ružica ; Kes, Petar ; Đanić, Davor ; Đanić, Ana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts of the Abstracts of the 14th Congress of the European Society for Organ Transplantation ; u: Transplant International 22 (2009) (S2) 1-394 ; Poster Presentations 1 ; 95-222 ; P-213 / - , 2009, 148-148

Skup
Congress of the European Society for Organ Transplantation (14 ; 2009)

Mjesto i datum
Pariz, Francuska, 15.09.2009. - 19.09.2009

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
renal transplantation; metabolic bone disease; endemic nephropathy

Sažetak
Metabolic bone disease is common in renal transplant recipients and frequently manifests with pain, fracture, osteonecrosis or avascular necrosis. These complications significantly impair quality of life and increase mortality and need for hospitalizations. In the present study we evaluated bone status of renal transplant recipients with Balkan endemic nephropathy (BEN). There were 10 female and 9 male patients with BEN age at transplantation ranging from 47 to 68 years (mean 57 years), previously treated with hemodialysis for 1-14 (mean 5.5) years. Bone pain was present in 12 patients, 3 patients developed nephrolithiasis, and one patient had bone fracture. Intact PTH ranged from 3.52 to 17.8 (mean 7.47) pmol/L, mean BALP was 32.6 mg/L, mean vitamin D concentration was 55.6 mg/L. Mean octeocalcin value was 12.78 mg/L, and crosslaps 1.31 mg/L. Parathyroidectomy after transplantation was performed in 2 patients because of severe hypercalcemia, while three patients received pamindronate. Renal transplant recipients with other primary renal diseases and the mean age of 54 years had mean BALP 45.78 mg/L, iPTH 6.38 pmol/L, vit D 65.7 mg/L, crosslaps 1.18 mg/L and osteocalcin 15.65 mg/L. On bone densitometry at 6 months after transplantation femoral T score was -2, 11 (range 0.97 – 2, 8), antecubital -3, 7 (range 0, 65 – 4, 5) and vertebral -2, 01 (range 0, 87 – 4, 3). No further significant bone loss was observed after the first year, and bone mineral density remained relatively stable but low. Our results demonstrate that patients with BEN suffer from significant bone loss after renal transplantation. High serum calcium, relatively low PTH and low BAlP suggest adynamic bone disease. However, low osteocalcin and increased crosslaps indicate increased bone resorption, which is higher then in renal transplant recipients with other primary renal diseases.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

Napomena
DOI: 10.1111/j.1432-2277.2009.00958.x

POVEZANOST RADA