Naslov
Influence of heredity and environment on peak bone density: a parent-offspring study

Autori
Cvijetić, Selma ; Colić Barić, Irena ; Šatalić, Zvonimir

Izvornik
Journal of clinical densitometry (1094-6950) 13 (2010), 3; 301-306

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Bone mineral density ; family study ; heredity ; environment ; physical activity

Sažetak
The aim of the study was to determine the relative influence of heredity and environment on peak bone density and also to estimate the risk of having low peak bone density if the bone density of parents is low. The study comprised 83 families (48 daughters and 35 sons and their parents). The children were at an age when bone density is at its peak at most skeletal sites (22.2±1.8 girls ; 23.1±1.2 boys). Bone mineral density (BMD ; g/cm2) was determined by dual energy absorptiometry (DXA). Anthropometric measurements, assessment of calcium intake and physical activity were also determined. Heredity accounted for 22-42% of the variation in BMD of the children, depending on the skeletal site. Heritability for cortical BMD of mid-radius was considerably lower than for spinal trabecular BMD. Children whose parents had low BMD (T score < -1) were 1.1 times more likely to inherit low BMD. Child BMD depended significantly on parent BMD and also on physical activity. In our study, heredity accounted for more than environmental factors for the total BMD variation. This influence was lower in the cortical than in the trabecular parts of the skeleton. Optimal environmental factors such as physical activity may influence the risk of inheriting low BMD.

Izvorni jezik
Engleski

Znanstvena područja
Prehrambena tehnologija

POVEZANOST RADA