Pregled bibliografske jedinice broj: 448502
PARKINSON'S DISEASE
PARKINSON'S DISEASE // Acta clinica Croatica, 48 (2009), 377-380 (recenziran, pregledni rad, stručni)
CROSBI ID: 448502 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
PARKINSON'S DISEASE
Autori
Bene, Raphael ; Antić, Sonja ; Budišić, Mislav ; Lisak, Marijana ; Trkanjec, Zlatko ; Demarin, Vida ; Podobnik-Šarkanji, Slava
Izvornik
Acta clinica Croatica (0353-9466) 48
(2009);
377-380
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, stručni
Ključne riječi
Parkinson disease - etiology; Parkinson disease - diagnosis; Parkinson disease - therapy
Sažetak
Parkinson's disease is one of the most common neurodegenerative diseases caused by degeneration of dopaminergic neurons in substantia nigra . The neuropathologic hallmark of Parkinson's disease is the presence of Lewy bodies composed mostly of alpha-synuc1ein and ubiquitin. It is believed that the occurrence of Parkinson's disease is due to a combination of genetic and environmental factors, but the exact mechanism of Parkinson's disease development is not fully elucidated. The most characteristic motor symptoms for Parkinson's disease include bradykinesia, rigidity, resting tremor and postural instability, while many patients also have non-motor signs and symptoms. The key therapeutic agent in the treatment of Parkinson's disease is L-dopa, and the others are dopaminergic agents, monoamine oxidase-B (MAO-B) inhibitors, catechol-O- methyltransferase (COMT) inhibitors, amantadine and anticholinergic agents.
Izvorni jezik
Engleski
Znanstvena područja
Kliničke medicinske znanosti
POVEZANOST RADA
Projekti:
134-1340036-0033 - Uloga genetskih markera u razvoju cerebralne aterosklerotske bolesti (Demarin, Vida, MZOS ) ( CroRIS)
134-1340036-0034 - Funkcijska dijagnostika moždane cirkulacije (Lovrenčić-Huzjan, Arijana, MZOS ) ( CroRIS)
134-1340036-0035 - Uloga vaskularnih čimbenika rizika u patogenezi Alzheimerove bolesti (Trkanjec, Zlatko, MZOS ) ( CroRIS)
Ustanove:
KBC "Sestre Milosrdnice"
Profili:
Slava Podobnik-Šarkanji (autor)
Sonja Antić (autor)
Mislav Budišić (autor)
Marijana Lisak (autor)
Vida Demarin (autor)
Zlatko Trkanjec (autor)
Raphael Bene (autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE