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Pregled bibliografske jedinice broj: 447763

Acid-base properties of functionalised tripodal polyamines and their interaction with nucleotides and nucleic acids

Sornosa-Ten, Alejandra; Albelda, M. Teresa; Frías, Juan C.; García-España, Enrique; Llinares, José M.; Budimir, Ana; Piantanida, Ivo
Acid-base properties of functionalised tripodal polyamines and their interaction with nucleotides and nucleic acids // Organic & biomolecular chemistry, 8 (2010), 11; 2567-2574 doi:10.1039/c000124d (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 447763 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Acid-base properties of functionalised tripodal polyamines and their interaction with nucleotides and nucleic acids

Autori
Sornosa-Ten, Alejandra ; Albelda, M. Teresa ; Frías, Juan C. ; García-España, Enrique ; Llinares, José M. ; Budimir, Ana ; Piantanida, Ivo

Izvornik
Organic & biomolecular chemistry (1477-0520) 8 (2010), 11; 2567-2574

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
tripodal polyamines; DNA and RNA interactions; RNA selectivity; nucleotides

Sažetak
Novel, highly positively charged tripodal polyamines with appended heterocyclic moieties revealed an intriguing panel of protonation species within the biologically relevant range. Studied compounds bind nucleotide monophosphates by mostly electrostatic interactions but only the imidazole analogue showed selectivity toward UMP in respect to other nucleotides. Strong binding of all the studied compounds to both ds-DNA and ds-RNA is to some extent selective toward the latter, showing rather rare RNA over DNA preference.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Temeljne medicinske znanosti



POVEZANOST RADA

Projekti:
098-0982914-2918 - Dizajn, sinteza i ispitivanje interakcija malih molekula s DNA, RNA i proteinima (Piantanida, Ivo, MZOS ) ( CroRIS)

Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb,
Institut "Ruđer Bošković", Zagreb

Profili:

Avatar Url Ana Budimir (autor)

Avatar Url Ivo Piantanida (autor)

Poveznice na cjeloviti tekst rada:

doi fulir.irb.hr www.rsc.org

Citiraj ovu publikaciju:

Sornosa-Ten, Alejandra; Albelda, M. Teresa; Frías, Juan C.; García-España, Enrique; Llinares, José M.; Budimir, Ana; Piantanida, Ivo
Acid-base properties of functionalised tripodal polyamines and their interaction with nucleotides and nucleic acids // Organic & biomolecular chemistry, 8 (2010), 11; 2567-2574 doi:10.1039/c000124d (međunarodna recenzija, članak, znanstveni)
Sornosa-Ten, A., Albelda, M., Frías, J., García-España, E., Llinares, J., Budimir, A. & Piantanida, I. (2010) Acid-base properties of functionalised tripodal polyamines and their interaction with nucleotides and nucleic acids. Organic & biomolecular chemistry, 8 (11), 2567-2574 doi:10.1039/c000124d.
@article{article, author = {Sornosa-Ten, Alejandra and Albelda, M. Teresa and Fr\'{\i}as, Juan C. and Garc\'{\i}a-Espa\~{n}a, Enrique and Llinares, Jos\'{e} M. and Budimir, Ana and Piantanida, Ivo}, year = {2010}, pages = {2567-2574}, DOI = {10.1039/c000124d}, keywords = {tripodal polyamines, DNA and RNA interactions, RNA selectivity, nucleotides}, journal = {Organic and biomolecular chemistry}, doi = {10.1039/c000124d}, volume = {8}, number = {11}, issn = {1477-0520}, title = {Acid-base properties of functionalised tripodal polyamines and their interaction with nucleotides and nucleic acids}, keyword = {tripodal polyamines, DNA and RNA interactions, RNA selectivity, nucleotides} }
@article{article, author = {Sornosa-Ten, Alejandra and Albelda, M. Teresa and Fr\'{\i}as, Juan C. and Garc\'{\i}a-Espa\~{n}a, Enrique and Llinares, Jos\'{e} M. and Budimir, Ana and Piantanida, Ivo}, year = {2010}, pages = {2567-2574}, DOI = {10.1039/c000124d}, keywords = {tripodal polyamines, DNA and RNA interactions, RNA selectivity, nucleotides}, journal = {Organic and biomolecular chemistry}, doi = {10.1039/c000124d}, volume = {8}, number = {11}, issn = {1477-0520}, title = {Acid-base properties of functionalised tripodal polyamines and their interaction with nucleotides and nucleic acids}, keyword = {tripodal polyamines, DNA and RNA interactions, RNA selectivity, nucleotides} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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