Pregled bibliografske jedinice broj: 44585
Thiorphan, an inhibitor of enkephalinase (CD10) does not affect proliferation of human K562 erythroleukemia cells
Thiorphan, an inhibitor of enkephalinase (CD10) does not affect proliferation of human K562 erythroleukemia cells // Current Studies in Biotechnology, Volume I. -Biomedicine / Kniewald, Zlatko i sur. (ur.).
Zagreb: Croatian Society for Biotechnology, 2000. str. 85-87 (poster, domaća recenzija, cjeloviti rad (in extenso), znanstveni)
CROSBI ID: 44585 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Thiorphan, an inhibitor of enkephalinase (CD10) does not affect proliferation of human K562 erythroleukemia cells
Autori
Breljak, Davorka ; Boranić, Milivoj
Vrsta, podvrsta i kategorija rada
Radovi u zbornicima skupova, cjeloviti rad (in extenso), znanstveni
Izvornik
Current Studies in Biotechnology, Volume I. -Biomedicine
/ Kniewald, Zlatko i sur. - Zagreb : Croatian Society for Biotechnology, 2000, 85-87
Skup
Scientific Conference Biotechnology and Biomedicine, with international participation
Mjesto i datum
Zagreb, Hrvatska, 22.02.1999. - 23.02.1999
Vrsta sudjelovanja
Poster
Vrsta recenzije
Domaća recenzija
Ključne riječi
erythroleukemia cell line; CD10; thiorphan; cell proliferation
Sažetak
This study explored the effect of thiorphan, a synthetic inhibitor of membrane metallopeptidase (enkephalinase EC 3.4.24.11, CD10) on proliferation of the human erythroleukemia cell line K562. The proliferation was measured after the incubation of the cells with thiorphan for 1 and 3 or 2, 4 and 6 days. A colorimetric assay based on the cleavage of the tetrazolium salt WST-1 by mitochondrial dehidrogenases in viable cells was used for that purpose. Thiorphan did not affect the proliferation of K562 cells, although the cells do express CD10. Thus, the CD10 membrane metallopeptidase seems not to play a significant role in the control of K562 cells proliferation rate.
Izvorni jezik
Engleski
Znanstvena područja
Kliničke medicinske znanosti
