Association of Nephrolithiasis and Gene for Glucose Transporter Type 9 (SLC2A9) : Study of 145 Patients

Polašek, Ozren; Gunjača, Grgo; Kolčić, Ivana; Zgaga, Lina; Džijan, Snježana; Smolić, Robert; Smolić, Martina; Milas-Ahić, Jasminka; Šerić, Vatroslav; Galić, Josip; Tucak-Zorić, Sandra; Tucak, Antun; Rudan, Igor; Lauc, Gordan

doi:10.3325/cmj.2010.51.48

Pregled bibliografske jedinice broj: 445187

Association of Nephrolithiasis and Gene for Glucose Transporter Type 9 (SLC2A9) : Study of 145 Patients

Polašek, Ozren; Gunjača, Grgo; Kolčić, Ivana; Zgaga, Lina; Džijan, Snježana; Smolić, Robert; Smolić, Martina; Milas-Ahić, Jasminka; Šerić, Vatroslav; Galić, Josip et al.

Association of Nephrolithiasis and Gene for Glucose Transporter Type 9 (SLC2A9) : Study of 145 Patients // Croatian medical journal, 51 (2010), 1; 48-53 doi:10.3325/cmj.2010.51.48 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 445187 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Association of Nephrolithiasis and Gene for Glucose Transporter Type 9 (SLC2A9) : Study of 145 Patients

Autori
Polašek, Ozren ; Gunjača, Grgo ; Kolčić, Ivana ; Zgaga, Lina ; Džijan, Snježana ; Smolić, Robert ; Smolić, Martina ; Milas-Ahić, Jasminka ; Šerić, Vatroslav ; Galić, Josip ; Tucak-Zorić, Sandra ; Tucak, Antun ; Rudan, Igor ; Lauc, Gordan

Izvornik
Croatian medical journal (0353-9504) 51 (2010), 1; 48-53

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
nephrolithiasis; uric acid; SLC2A9

Sažetak
To investigate the association of nephrolithiasis and solute carrier family 2, facilitated glucose transporter, member 9 (SLC2A9), also known as glucose transporter type 9, Glut9. A total of 145 participants were recruited in the period April-October 2008 from the Department of Mineral Research at the Medical School Osijek, Osijek, Croatia ; 58 (40%) had confirmed nephrolithiasis and 87 (60%) were asymptomatic. Four single nucleotide polymorphisms (SNP) from the SLC2A9 gene were genotyped in both groups (rs733175, rs6449213, rs1014290, and rs737267). There was a weak but significant association of all 4 SNPs and nephrolithiasis (P=0.029 for rs733175 ; P=0.006 for rs6449213 ; P=0.020 for rs1014290, and P=0.011 for rs737267). Logistic regression in an age- and sex-adjusted model suggested that genotype C/T for rs6449213 had odds ratio for nephrolithiasis of 2.89 (95% confidence interval, 1.13-7.40). This SNP explained a total of 4.4% of nephrolithiasis variance. Development of nephrolithiasis may be associated with SLC2A9 gene. Further studies are needed to clarify the role of SLC2A9 gene as a link between uric acid and nephrolithiasis.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti, Javno zdravstvo i zdravstvena zaštita

POVEZANOST RADA

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216-1080315-0302 - Odrednice zdravlja i bolesti u općoj i izoliranim ljudskim populacijama (Polašek, Ozren, MZOS ) ( CroRIS)
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219-2192190-2069 - Fizikalno-kemijski i metabolički čimbenici rizika stvaranja kamenaca (Včev, Aleksandar, MZOS ) ( CroRIS)
219-2192190-2182 - Osobitosti koštane pregradnje u bolesnika s urolitijazom (Milas-Ahić, Jasminka, MZOS ) ( CroRIS)
219-2192190-2186 - Prevencija stvaranja i recidiva mokraćnih kamenca (Tucak, Antun, MZOS ) ( CroRIS)

Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb,
Medicinski fakultet, Zagreb,
Medicinski fakultet, Split,
Medicinski fakultet, Osijek,
GENOS d.o.o.

Profili:

Snježana Džijan (autor)