Naslov
Association between selective IgA and IgE deficiency

Autori
Mrkić, Iva ; Zrinski, Renata ; Stanić, Barbara ; Dodig, Slavica ; Plavec, Davor ; Turkalj, Mirjana.

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo

Skup
Pediatric Allergy and Asthma Meeting

Mjesto i datum
Venecija, Italija, 12.11.2009. - 14.11.2009

Vrsta sudjelovanja
Ostalo

Vrsta recenzije
Nije recenziran

Ključne riječi
immunodeficiency; IgA; IgE; children

Sažetak
Selective IgA deficiency is the most common primary immunodeficiency and it is often associated with atopy, recurrent infections and high IgE levels. Some small studies demonstrated the association between low serum level of IgE and selective IgA deficiency. Aim of our study was to evaluate the prevalence of selective IgA deficiency and IgE deficiency in our hospital during the period of 2007-2008, and to investigate the association between them. Material and methods: During the period of 2007-2008, our laboratory performed 12 675 eletrophoresis of serum proteins and total IgE measurements. We collected data (frequency of respiratory tract infections, history of atopy) in patients with selective IgA deficiency (IgA level<2 SDs below normal for age but with normal serum IgG and IgM levels)and low IgE levels (total IgE<2.5 IU/L). all patients aged <3 were excluded. Results: From 12 675 performed analyses, total of 110 children (age 0-17)had low IgE or IgA levels. 73 children (32 male) had decreased IgE level(0.57%), and 41 children (22 male) had decreased IgA level (0.32%). After excluding all children under age of three and children with other immunologic disorders we found total of 45 children with either selective IgA or IgE deficiency (0.36%, age 3-17). 28 of them had selective IgE deficiency (0.22%) and 17 had selective IgA deficiency (0.13%). In this group of 45 children none of them had both levels of immunoglobulin decreased. Statistically significant inverse association was found between serum IgA and IgE levels (r=0.586, P=0.0001) showing that children with decreased IgA levels had higher IgE levels. No significant difference between two groups was found for the number of respiratory tract and family and personal history of atopy. Conclusion: Children with selective IgA deficiency did not have IgE deficiency. IgE deficient patients have comparable number of respiratory tract infections to children with selective IgA deficiency, which is proven to have increased number of respiratory tract infections. These results indicate that IgE can have an important role in immune response to respiratory pathogenes as well.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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