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Pregled bibliografske jedinice broj: 438789

Genome-wide association study identifies five loci associated with lung function

Repapi, Emmanouela; Sayers, Ian; Wain, Louise V; Burton, Paul R; Johnson, Toby; Obeidat, Ma'en; Zhao, Jing Hua; Ramasamy, Adaikalavan; Zhai, Guangju; Vitart, Veronique et al.
Genome-wide association study identifies five loci associated with lung function // Nature genetics, 42 (2010), 12; 36-44 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 438789 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Genome-wide association study identifies five loci associated with lung function

Autori
Repapi, Emmanouela ; Sayers, Ian ; Wain, Louise V ; Burton, Paul R ; Johnson, Toby ; Obeidat, Ma'en ; Zhao, Jing Hua ; Ramasamy, Adaikalavan ; Zhai, Guangju ; Vitart, Veronique ; Huffman, Jennifer E ; Igl, Wilmar ; Albrecht, Eva ; Deloukas, Panos ; Henderson, John ; Granell, Raquel ; McArdle, Wendy L ; Rudnicka, Alicja R ; Barroso, Inês ; Loos, Ruth J F ; Wareham, Nicholas J ; Mustelin, Linda ; Rantanen, Taina ; Surakka, Ida ; Imboden, Medea ; H Wichmann, Erich ; Grković, Ivica ; Janković, Stipan ; Zgaga, Lina ; Hartikainen, Anna-Liisa ; Peltonen, Leena ; Gyllensten, Ulf ; Johansson, Åsa ; Zaboli, Ghazal ; Campbell, Harry ; Wild, Sarah H ; Wilson, James F ; Glaser, Sven ; Homuth, Georg ; Völzke, Henry ; Mangino, Massimo ; Soranzo, Nicole ; Spector, Tim D ; Polašek, Ozren ; Rudan, Igor ; Wright, Alan F ; Heliövaara, Markku ; Ripati, Samuli ; Pouta, Anneli ; Naluai, Åsa Torinsson ; Olin, Anna-Carin ; Torén, Kjell ; Cooper, Matthew N ; James, Alan L ; Palmer, Lyle J ; Hingorani, Aroon D ; Wannamethee, S Goya ; Whincup, Peter H ; Davey Smith, George ; Ebrahim, Shah ; McKeever, Tricia M ; Pavord, Ian D ; MacLeod, Andrew K ; Morris, Andrew D ; Porteous, David J ; Cooper, Cyrus ; Dennison, Elaine ; Shaheen, Seif ; Karrasch, Stefan ; Schnabel, Eva ; Schulz, Holger ; Grallert, Harald ; Bouatia-Naji, Nabila ; Delplanque, Jérôme ; Froguel, Philippe ; Blakey, John D ; Britton, John R ; Morris, Richard W ; Holloway, John W ; Lawlor, Debbie A ; Hui, Jennie ; Nyberg, Fredrik ; Jarvelin, Marjo-Riitta ; Jackson, Cathy ; Kähönen, Mika ; Kaprio, Jaakko ; Probst-Hensch, Nicole M ; Koch, Beate ; Hayward, Caroline ; Evans, David M ; Elliot, Paul ; Strachan, David P ; Hall, Ian P ; Tobin, Martin D

Izvornik
Nature genetics (1061-4036) 42 (2010), 12; 36-44

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
genome-wide association study; lung function

Sažetak
Pulmonary function measures are heritable traits that predict morbidity and mortality and define chronic obstructive pulmonary disease (COPD). We tested genome-wide association with forced expiratory volume in 1 s (FEV1) and the ratio of FEV1 to forced vital capacity (FVC) in the SpiroMeta consortium (n = 20, 288 individuals of European ancestry). We conducted a meta-analysis of top signals with data from direct genotyping (n ≤ 32, 184 additional individuals) and in silico summary association data from the CHARGE Consortium (n = 21, 209) and the Health 2000 survey (n ≤ 883). We confirmed the reported locus at 4q31 and identified associations with FEV1 or FEV1/FVC and common variants at five additional loci: 2q35 in TNS1 (P = 1.11 × 10−12), 4q24 in GSTCD (2.18 × 10−23), 5q33 in HTR4 (P = 4.29 × 10−9), 6p21 in AGER (P = 3.07 × 10−15) and 15q23 in THSD4 (P = 7.24 × 10−15). mRNA analyses showed expression of TNS1, GSTCD, AGER, HTR4 and THSD4 in human lung tissue. These associations offer mechanistic insight into pulmonary function regulation and indicate potential targets for interventions to alleviate respiratory disease.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita



POVEZANOST RADA

Projekti:
216-0000000-0525 - Rana dijagnostika i trombolitičko liječenje ishemijskog moždanog udara (Janković, Stipan, MZOS ) ( CroRIS)
216-1080315-0302 - Odrednice zdravlja i bolesti u općoj i izoliranim ljudskim populacijama (Polašek, Ozren, MZOS ) ( CroRIS)
216-2160528-0067 - Mehanizmi srčane boli u ishemiji, metaboličkim promjenama i u starosti (Grković, Ivica, MZOS ) ( CroRIS)

Ustanove:
Medicinski fakultet, Split

Profili:

Avatar Url Stipan Janković (autor)

Avatar Url Lina Zgaga (autor)

Avatar Url Ozren Polašek (autor)

Avatar Url Ivica Grković (autor)

Avatar Url Igor Rudan (autor)

Citiraj ovu publikaciju:

Repapi, Emmanouela; Sayers, Ian; Wain, Louise V; Burton, Paul R; Johnson, Toby; Obeidat, Ma'en; Zhao, Jing Hua; Ramasamy, Adaikalavan; Zhai, Guangju; Vitart, Veronique et al.
Genome-wide association study identifies five loci associated with lung function // Nature genetics, 42 (2010), 12; 36-44 (međunarodna recenzija, članak, znanstveni)
Repapi, E., Sayers, I., Wain, L., Burton, P., Johnson, T., Obeidat, M., Zhao, J., Ramasamy, A., Zhai, G. & Vitart, V. (2010) Genome-wide association study identifies five loci associated with lung function. Nature genetics, 42 (12), 36-44.
@article{article, author = {Repapi, Emmanouela and Sayers, Ian and Wain, Louise V and Burton, Paul R and Johnson, Toby and Obeidat, Ma'en and Zhao, Jing Hua and Ramasamy, Adaikalavan and Zhai, Guangju and Vitart, Veronique and Huffman, Jennifer E and Igl, Wilmar and Albrecht, Eva and Deloukas, Panos and Henderson, John and Granell, Raquel and McArdle, Wendy L and Rudnicka, Alicja R and Barroso, In\^{e}s and Loos, Ruth J F and Wareham, Nicholas J and Mustelin, Linda and Rantanen, Taina and Surakka, Ida and Imboden, Medea and H Wichmann, Erich and Grkovi\'{c}, Ivica and Jankovi\'{c}, Stipan and Zgaga, Lina and Hartikainen, Anna-Liisa and Peltonen, Leena and Gyllensten, Ulf and Johansson, \AAsa and Zaboli, Ghazal and Campbell, Harry and Wild, Sarah H and Wilson, James F and Glaser, Sven and Homuth, Georg and V\"{o}lzke, Henry and Mangino, Massimo and Soranzo, Nicole and Spector, Tim D and Pola\v{s}ek, Ozren and Rudan, Igor and Wright, Alan F and Heli\"{o}vaara, Markku and Ripati, Samuli and Pouta, Anneli and Naluai, \AAsa Torinsson and Olin, Anna-Carin and Tor\'{e}n, Kjell and Cooper, Matthew N and James, Alan L and Palmer, Lyle J and Hingorani, Aroon D and Wannamethee, S Goya and Whincup, Peter H and Davey Smith, George and Ebrahim, Shah and McKeever, Tricia M and Pavord, Ian D and MacLeod, Andrew K and Morris, Andrew D and Porteous, David J and Cooper, Cyrus and Dennison, Elaine and Shaheen, Seif and Karrasch, Stefan and Schnabel, Eva and Schulz, Holger and Grallert, Harald and Bouatia-Naji, Nabila and Delplanque, J\'{e}r\^{o}me and Froguel, Philippe and Blakey, John D and Britton, John R and Morris, Richard W and Holloway, John W and Lawlor, Debbie A and Hui, Jennie and Nyberg, Fredrik and Jarvelin, Marjo-Riitta and Jackson, Cathy and K\"{a}h\"{o}nen, Mika and Kaprio, Jaakko and Probst-Hensch, Nicole M and Koch, Beate and Hayward, Caroline and Evans, David M and Elliot, Paul and Strachan, David P and Hall, Ian P and Tobin, Martin D}, year = {2010}, pages = {36-44}, keywords = {genome-wide association study, lung function}, journal = {Nature genetics}, volume = {42}, number = {12}, issn = {1061-4036}, title = {Genome-wide association study identifies five loci associated with lung function}, keyword = {genome-wide association study, lung function} }
@article{article, author = {Repapi, Emmanouela and Sayers, Ian and Wain, Louise V and Burton, Paul R and Johnson, Toby and Obeidat, Ma'en and Zhao, Jing Hua and Ramasamy, Adaikalavan and Zhai, Guangju and Vitart, Veronique and Huffman, Jennifer E and Igl, Wilmar and Albrecht, Eva and Deloukas, Panos and Henderson, John and Granell, Raquel and McArdle, Wendy L and Rudnicka, Alicja R and Barroso, In\^{e}s and Loos, Ruth J F and Wareham, Nicholas J and Mustelin, Linda and Rantanen, Taina and Surakka, Ida and Imboden, Medea and H Wichmann, Erich and Grkovi\'{c}, Ivica and Jankovi\'{c}, Stipan and Zgaga, Lina and Hartikainen, Anna-Liisa and Peltonen, Leena and Gyllensten, Ulf and Johansson, \AAsa and Zaboli, Ghazal and Campbell, Harry and Wild, Sarah H and Wilson, James F and Glaser, Sven and Homuth, Georg and V\"{o}lzke, Henry and Mangino, Massimo and Soranzo, Nicole and Spector, Tim D and Pola\v{s}ek, Ozren and Rudan, Igor and Wright, Alan F and Heli\"{o}vaara, Markku and Ripati, Samuli and Pouta, Anneli and Naluai, \AAsa Torinsson and Olin, Anna-Carin and Tor\'{e}n, Kjell and Cooper, Matthew N and James, Alan L and Palmer, Lyle J and Hingorani, Aroon D and Wannamethee, S Goya and Whincup, Peter H and Davey Smith, George and Ebrahim, Shah and McKeever, Tricia M and Pavord, Ian D and MacLeod, Andrew K and Morris, Andrew D and Porteous, David J and Cooper, Cyrus and Dennison, Elaine and Shaheen, Seif and Karrasch, Stefan and Schnabel, Eva and Schulz, Holger and Grallert, Harald and Bouatia-Naji, Nabila and Delplanque, J\'{e}r\^{o}me and Froguel, Philippe and Blakey, John D and Britton, John R and Morris, Richard W and Holloway, John W and Lawlor, Debbie A and Hui, Jennie and Nyberg, Fredrik and Jarvelin, Marjo-Riitta and Jackson, Cathy and K\"{a}h\"{o}nen, Mika and Kaprio, Jaakko and Probst-Hensch, Nicole M and Koch, Beate and Hayward, Caroline and Evans, David M and Elliot, Paul and Strachan, David P and Hall, Ian P and Tobin, Martin D}, year = {2010}, pages = {36-44}, keywords = {genome-wide association study, lung function}, journal = {Nature genetics}, volume = {42}, number = {12}, issn = {1061-4036}, title = {Genome-wide association study identifies five loci associated with lung function}, keyword = {genome-wide association study, lung function} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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