Naslov
Design optimisation of novel peptide antibiotics predicted to have high selectivity against G-negative bacteria

Autori
Juretić, Davor ; Vukičević, Damir ; Ilić, Nada ; Bojović, Viktor ; Tossi, Alessandro

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
The 3rd Adriatic Meeting on Computational Solutions in the Life Sciences / Tomić, Sanja ; Smith, David - Zagreb : Centre for Computational Solutions in the Life Sciences, Ruđer Bošković Institute, 2009, 59-59

ISBN
978-953-6690-80-0

Skup
The 3rd Adriatic Meeting on Computational Solutions in the Life Sciences

Mjesto i datum
Primošten, Hrvatska, 01.09.2009. - 05.09.2009

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
peptide antibiotics; design principles; Gram-negative bacteria

Sažetak
Competing with nature in creating effective peptide antibiotics, specific software has been created (Designer). Next logical step was to optimise it. Several calculations have been done, all for very short peptide antibiotics (16 – 23 AA), but long enough to bridge the cell membrane. The software offered as output glycine-rich peptides. We selected three of them as very promising ones. The criteria were a) the existence of at least three small motives (GxxxG or GxxxxxxG) in the sequence, b) net charge of +4/+5, c) high predicted therapeutic index and d) high value of hydrophobic moment for helical conformation in the membrane. The Split server (http://split.pmfst.hr/split/) was consulted which, based on our earlier investigations, confirmed the theory that selected peptides are promising antimicrobial peptides (Figure 1).

Izvorni jezik
Engleski

Znanstvena područja
Fizika, Biologija

POVEZANOST RADA