Naslov
Release of Pro- and Anti-Inflammatory Cytokines During Spinal Anaesthesia in Patients Undergoing Transurethral Resection of The Prostate

Autori
Šakić, Katarina

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstract of the XXVIII Annual ESRA Congres of Europen Sociaty of Regional Anaesthesia & Pain ; u: Regional Anesthesia and Pain Medicine 34 (2009) (5)(S1) ; 1-398 / - , 2009, 58-58

Skup
Annual ESRA Congress (28 ; 2009)

Mjesto i datum
Salzburg, Austrija, 09.09.2009. - 12.09.2009

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
spinal anaesthesia; cytokines

Sažetak
Anaesthesia may indirectly affect the immune system of surgical patients by modulating neurohormonal stress response. The aim of the study is to establish whether the examined cytokines either individually or in certain correlations may characterize regional (spinal) anaesthesia. 18 patients with American Society of Anaesthesiologis status I or II who were scheduled for TURP (transurethral resection of the prostate) were anaesthetized in spinal anaesthesia. Peripheral venous blood samples were collected 2 hours before surgery, on the first, third and fifth postoperative days. We have measured pro-inflamatory cytokines (IL-1α ; IL-1β ; TNF-α ; IL-6 ; IL-8 ; MCP-1 ; VEGF ; EGF), anti-inflamatory cytokines (IL-4 ; IL-10), and cytokines which are secreted by Th 1 helper lymphocytes (IL- 2 ; IFN-γ) in order to establish differencies in patients before and after surgery. Serum concentration of pro-inflamatory cytokines (IL-1α ; IL-1β ; TNF-α ; IL-8 ; MCP-1 ; VEGF ; EGF), anti-inflamatory cytokines (IL-4 ; IL-10), and cytokines which are secreted by Th 1 helper lymphocytes (IL- 2 ; IFN-γ) show no statisticaly difference in values before and after surgery. Only serum concentration of IL-6 was significantly (P< 0.05) increased on the first postoperative day and than decreased on the third postoperative day. Surgery-related postoperative release of the proinflammatory cytokine IL-6 was increased in patients after spinal anaestesia with no increased levels of the typical Th1 cytokine IFN-γ and no increase of cytokines such as IL-10 and IL-4 which are associated with T-helper type 2 (Th2)-like immune response. Spinal anaesthesia results in lessimmunosupression, i.e. maintains the number of Th1 cells, thus stimulating the cell immunity. Immunosuppression to tissue injury may have relevance in patients with preexisting immune dysfunctions.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA