Naslov
DNA-protective effects of EGCG and propolis in alloxan–induced diabetic mice

Autori
Oršolić, Nada ; Gajski, Goran ; Josipović, Pavle ; Garaj-Vrhovac, Verica ; Sirovina, Damir

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Annual meeting of the Croatian Immunological Society 2009 : abstracts / Rabatić, Sabina - Zagreb : Hrvatsko imunološko društvo, 2009, 29-29

Skup
Annual meeting of the Croatian Immunological Society

Mjesto i datum
Starigrad, Hrvatska, 01.10.2009. - 04.10.2009

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Domaća recenzija

Ključne riječi
cancer; propolis; polyphenols; EGCG; alloxan

Sažetak
Free radicals have been implicated in playing a role in over 100 diseases, including cancer, atherosclerosis, rheumatoid arthritis, inflammatory bowel disease, diabetes, asthma, cardiovascular disease, liver disease, and other inflammatory processes. There is growing recognition that many polyphenolic compounds presents in most plants and bee products such as propolis, may have beneficial effect on human health. Tea catechins are polyphenolic flavonoids which have been found to possess widespread biological functions including obesity and diabetes. Tea catechins, especially (–)-epigallocatechin gallate (EGCG), appear to have antiobesity and antidiabetic effects. The present study was designed to elucidate the antidiabetic effect of (–)-epicatechin and propolis in alloxan-induced diabetes in mice. Intraperitoneal administration of (–)-epicatechin or propolis at doses of 50 mg/kg to diabetic mice for a period of 7 days resulted in a significant changes in body weight, haematological and some biochemical parameter of blood. (–)-Epicatechin at a dose of 50 mg/kg was found to be more effective than propolis. Additionally mouse blood lymphocytes were utilized to check for possible protective effects of EGCG or propolis against alloxan-induced oxidative DNA-damage. EGCG or propolis significantly reduces oxidative cell damage in diabetic mice. The results from the genotoxicity studies suggest EGCG or propolis is safe for consumption with no observed adverse effect

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti, Veterinarska medicina

POVEZANOST RADA