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Pregled bibliografske jedinice broj: 432488

Primary DNA damage assessed with the comet assay and comparison to the absorbed dose of diagnostic X-rays in children


Milković, Đurđica; Garaj-Vrhovac, Vera; Ranogajec-Komor, Maria; Miljanić, Saveta; Gajski, Goran; Knežević, Željka; Beck, Natko
Primary DNA damage assessed with the comet assay and comparison to the absorbed dose of diagnostic X-rays in children // International Journal of Toxicology, 28 (2009), 5; 405-416 doi:10.1177/1091581809344775 (međunarodna recenzija, članak, znanstveni)


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Naslov
Primary DNA damage assessed with the comet assay and comparison to the absorbed dose of diagnostic X-rays in children

Autori
Milković, Đurđica ; Garaj-Vrhovac, Vera ; Ranogajec-Komor, Maria ; Miljanić, Saveta ; Gajski, Goran ; Knežević, Željka ; Beck, Natko

Izvornik
International Journal of Toxicology (1091-5818) 28 (2009), 5; 405-416

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
x-ray dosimetry; DNA damage; human peripheral blood lymphocytes; alkaline comet assay; ALARA

Sažetak
The aim of this work is to assess DNA damage in peripheral blood lymphocytes of children prior to and following airway X-ray examinations of the chest using the alkaline comet assay and to compare data with the measured absorbed dose. Twenty children with pulmonary diseases, between the ages of 5 and 14 years, are assessed. Absorbed dose measurements are conducted for posterior-anterior projection on the forehead, thyroid gland, gonads, chest, and back. Doses are measured using thermoluminescent and radiophotoluminescent dosimetry systems. Differences between tail lengths, tail intensity, and tail moments as well as for the long-tailed nuclei before and after exposures are statistically significant and are dependent on the individual. The results demonstrate the usefulness of the comet assay as a measure of X-ray damage to lymphocytes in a clinical setting. Doses measured with both dosimeters show satisfactory agreement (0.01 mSv) and are suitable for dosimetric measurements in X-ray diagnostics.

Izvorni jezik
Engleski

Znanstvena područja
Biologija



POVEZANOST RADA


Projekti:
022-0222148-2125 - Mutageni i antimutageni u ekogenetičkim istraživanjima (Garaj-Vrhovac, Vera, MZOS ) ( CroRIS)
098-0982904-2954 - Fizičko-kemijski učinci ionizirajućih zračenja u materijalima (Mihaljević, Branka, MZOS ) ( CroRIS)
277-2770966-0962 - Učinci radioloških dijagnostičkih postupaka pri pregledu dišnih putova u djece (Milković, Đurđica, MZOS ) ( CroRIS)

Ustanove:
Institut za medicinska istraživanja i medicinu rada, Zagreb,
Institut "Ruđer Bošković", Zagreb

Poveznice na cjeloviti tekst rada:

doi

Citiraj ovu publikaciju:

Milković, Đurđica; Garaj-Vrhovac, Vera; Ranogajec-Komor, Maria; Miljanić, Saveta; Gajski, Goran; Knežević, Željka; Beck, Natko
Primary DNA damage assessed with the comet assay and comparison to the absorbed dose of diagnostic X-rays in children // International Journal of Toxicology, 28 (2009), 5; 405-416 doi:10.1177/1091581809344775 (međunarodna recenzija, članak, znanstveni)
Milković, Đ., Garaj-Vrhovac, V., Ranogajec-Komor, M., Miljanić, S., Gajski, G., Knežević, Ž. & Beck, N. (2009) Primary DNA damage assessed with the comet assay and comparison to the absorbed dose of diagnostic X-rays in children. International Journal of Toxicology, 28 (5), 405-416 doi:10.1177/1091581809344775.
@article{article, author = {Milkovi\'{c}, \DJur\djica and Garaj-Vrhovac, Vera and Ranogajec-Komor, Maria and Miljani\'{c}, Saveta and Gajski, Goran and Kne\v{z}evi\'{c}, \v{Z}eljka and Beck, Natko}, year = {2009}, pages = {405-416}, DOI = {10.1177/1091581809344775}, keywords = {x-ray dosimetry, DNA damage, human peripheral blood lymphocytes, alkaline comet assay, ALARA}, journal = {International Journal of Toxicology}, doi = {10.1177/1091581809344775}, volume = {28}, number = {5}, issn = {1091-5818}, title = {Primary DNA damage assessed with the comet assay and comparison to the absorbed dose of diagnostic X-rays in children}, keyword = {x-ray dosimetry, DNA damage, human peripheral blood lymphocytes, alkaline comet assay, ALARA} }
@article{article, author = {Milkovi\'{c}, \DJur\djica and Garaj-Vrhovac, Vera and Ranogajec-Komor, Maria and Miljani\'{c}, Saveta and Gajski, Goran and Kne\v{z}evi\'{c}, \v{Z}eljka and Beck, Natko}, year = {2009}, pages = {405-416}, DOI = {10.1177/1091581809344775}, keywords = {x-ray dosimetry, DNA damage, human peripheral blood lymphocytes, alkaline comet assay, ALARA}, journal = {International Journal of Toxicology}, doi = {10.1177/1091581809344775}, volume = {28}, number = {5}, issn = {1091-5818}, title = {Primary DNA damage assessed with the comet assay and comparison to the absorbed dose of diagnostic X-rays in children}, keyword = {x-ray dosimetry, DNA damage, human peripheral blood lymphocytes, alkaline comet assay, ALARA} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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