Naslov
In vivo experimental approach to treatment against tabun poisoning

Autori
Berend, Suzana ; Katalinić, Maja ; Lucić Vrdoljak, Ana ; Kovarik, Zrinka ; Kuča, Kamil ; Radić, Božica

Izvornik
Journal of enzyme inhibition and medicinal chemistry (1475-6366) 25 (2010), 4; 531-536

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
pretreatment; atropine; oxime; pyridostigmine; mice; tabun

Sažetak
Organophosphorous compounds pose potential threat to both military and civilian populations. Since post-exposure therapy has its limitations, our research was focused on the possibility of improving pretreatment in order to limit the toxic effects of tabun. We determined the protective index of various combinations of atropine, oximes (K074, K048 and TMB-4), and pyridostigmine given to mice before tabun intoxication. Although tested oximes showed very good therapeutic efficacy in tabun-poisoned mice, given pretreatments improved therapy against tabun poisoning. These regimens ensured survival of all animals up to 25.2 LD50 of tabun. Our results indicate that even pretreatment with atropine alone is sufficiently effective in enhancing the survival of mice poisoned by multiple doses of tabun, if oxime therapy follows. K048 is our oxime of choice for future research, as it shows better protective and reactivating potency.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Temeljne medicinske znanosti

POVEZANOST RADA