Naslov
Conversion of latent to recurrent MCMV infection is primarily controlled by CD8+ T lymphocytes and NK cells

Autori
Jonjić, Stipan ; Polić, Bojan ; Zorica, Irena ; Krmpotić, Astrid ; Pavić, Ivica ; Lučin, Pero ; Koszinowski, Ulrich

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
6th International Cytomegalovirus Workshop : Program and Abstracts / Pass, Robert F. - Orange Beach (AL) : UAB School of Medicine, 1997, A19-A19

Skup
6th International Cytomegalovirus Workshop

Mjesto i datum
Orange Beach (AL), Sjedinjene Američke Države, 05.03.1997. - 09.03.1997

Vrsta sudjelovanja
Ostalo

Vrsta recenzije
Nije recenziran

Ključne riječi
latent CMV infection; CD8+ T lymphocytes

Sažetak
Using B cell-deficient mice we demonstrated previously that antibodies are not essential for the resolution of primary cytomegalovirus infection. here we provide evidence that cell-mediated immune control mechanisms are able to maintain latent MCMV infection in the absence of detectable infectious virus. Depletion of both T cell subsets and NK cells led to recurrent CMV infection in the majority of latently infected B cell-deficient mice within seven days. Recurrent infection did not occur if only one of the subsets was depleted, indicating the functional redundancy of the immune control mechanisms. However, the individual capacity of these cell subsets in controlling of recurrent virus was not equal. In the absence of CD4+ T lymphocytes and NK cells, CD8+ T cells were able maintain nonproductive infection. The absence of CD8+ T cells could be compensated by the synergistic action of CD4+ T lymphocytes and NK cells. Either, CD4+ T cells or NK cells alone, however, were not sufficient to prevent recurrence of productive CMV. Furhermore, IFNg, produced by T cells and NK cells, was essential in CMV control, implicating, at least in part, noncytolytic control mechanisms. Altogether, we postulate that reactivation of latent CMV is a frequent event but the immune control limits viral replication at a stage prior to the production of infectious virus.

Izvorni jezik
Engleski

Znanstvena područja
Veterinarska medicina

POVEZANOST RADA