Blood selenium, glutathione peroxidase activity and antioxidant supplementation of subjects exposed to arsenic via drinking water

Ćavar, Suzana; Bošnjak, Zinka; Klapec, Tomislav; Barišić, Karmela; Čepelak, Ivana; Jurasović, Jasna; Milić, Marija

doi:10.1016/j.etap.2009.12.008

Pregled bibliografske jedinice broj: 427652

Blood selenium, glutathione peroxidase activity and antioxidant supplementation of subjects exposed to arsenic via drinking water

Ćavar, Suzana; Bošnjak, Zinka; Klapec, Tomislav; Barišić, Karmela; Čepelak, Ivana; Jurasović, Jasna; Milić, Marija

Blood selenium, glutathione peroxidase activity and antioxidant supplementation of subjects exposed to arsenic via drinking water // Environmental toxicology and pharmacology, 29 (2010), 2; 138-143 doi:10.1016/j.etap.2009.12.008 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 427652 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Blood selenium, glutathione peroxidase activity and antioxidant supplementation of subjects exposed to arsenic via drinking water

Autori
Ćavar, Suzana ; Bošnjak, Zinka ; Klapec, Tomislav ; Barišić, Karmela ; Čepelak, Ivana ; Jurasović, Jasna ; Milić, Marija

Izvornik
Environmental toxicology and pharmacology (1382-6689) 29 (2010), 2; 138-143

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
arsenic ; selenium ; glutathione peroxidase ; antioxidants ; catalase ; genetic polymorphisms

Sažetak
This work investigated serum selenium (Se) and glutathione peroxidase (GPx) levels in 25 Croatian subjects exposed to high levels of As from drinking water (median As level in urine: 620.74 mug/g creatinine) and 25 controls (32.98 mug/g creatinine). The exposed group had lower (p<0.001) median serum Se and GPx levels (Se: 82.34 vs 59.02 µ ; g/l ; GPx: 45.99 vs 38.38 U/g hemoglobin). A subsample of 20 exposed subjects took part in a two-month antioxidant supplementation trial which increased median GPx activity (30.71 to 40.98 U/g hemoglobin ; p=0.041) and reduced total urinary As (median 680.15 to 501.96 µ ; g/g creatinine ; p=0.051). The effect of selected catalase (-262C>T) and GPx1 (-593C>T) gene polymorphisms was also examined. The low Se status and GPx activity may heighten risk of adverse health effects, especially in genetically predisposed individuals. The outcome of antioxidant treatment indicates modulation of As metabolism and oxidative stress, relevance of which needs further research.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita

POVEZANOST RADA

Projekti:
006-0061117-1236 - Posttranskripcijsko utišavanje stresnih proteina pomoću siRNA nanoterapije (Barišić, Karmela, MZOS ) ( CroRIS)
006-0061117-1238 - Bioaktivne prirodne tvari: izolacija, karakterizacija i biološki učinci (Vladimir-Knežević, Sanda, MZOS ) ( CroRIS)
006-0061245-0977 - Molekularni mehanizmi patogeneze kronične opstrukcijske bolesti pluća (Žanić-Grubišić, Tihana, MZOS ) ( CroRIS)
022-0222148-2135 - Izloženost metalima i njihovi učinci u graviditetu i postnatalnom razdoblju (Piasek, Martina, MZOS ) ( CroRIS)
113-1130473-0334 - Sinergističke smjese u antifungalnoj i antimikotoksigenoj zaštiti hrane (Klapec, Tomislav, MZOS ) ( CroRIS)

Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb,
Institut za medicinska istraživanja i medicinu rada, Zagreb,
Prehrambeno-tehnološki fakultet, Osijek,
Nastavni zavod za javno zdravstvo "Dr. Andrija Štampar"

Profili:

Karmela Barišić (autor)