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Pregled bibliografske jedinice broj: 426441

Synthesis and characterization of thiosemicarbazonato molybdenum(VI) complexes and their in vitro antitumor activity

Vrdoljak, Višnja; Đilović, Ivica; Rubčić, Mirta; Kraljević Pavelić, Sandra; Kralj, Marijeta; Matković-Čalogović, Dubravka; Piantanida, Ivo; Novak, Predrag; Rožman, Andrea; Cindrić, Marina
Synthesis and characterization of thiosemicarbazonato molybdenum(VI) complexes and their in vitro antitumor activity // European journal of medicinal chemistry, 45 (2010), 1; 38-48 doi:10.1016/j.ejmech.2009.09.021 (međunarodna recenzija, članak, znanstveni)

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Naslov
Synthesis and characterization of thiosemicarbazonato molybdenum(VI) complexes and their in vitro antitumor activity

Autori
Vrdoljak, Višnja ; Đilović, Ivica ; Rubčić, Mirta ; Kraljević Pavelić, Sandra ; Kralj, Marijeta ; Matković-Čalogović, Dubravka ; Piantanida, Ivo ; Novak, Predrag ; Rožman, Andrea ; Cindrić, Marina

Izvornik
European journal of medicinal chemistry (0223-5234) 45 (2010), 1; 38-48

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
thiosemicarbazone ; molybdenum(VI) complexes ; X-ray crystal structures ; antiproliferative effects ; tumour cell lines

Sažetak
New dioxomolybdenum(VI) complexes were obtained by the reaction of [MoO2(acac)2] with thiosemicarbazone ligands derived from 3-thiosemicarbazide and 4-(diethylamino)salicylaldehyde (H2L1), 2-hydroxy-3-methoxybenzaldehyde (H2L2) or 2-hydroxy-1-naphthaldehyde (H2L3). In all complexes thiosemicarbazonato ligands are coordinated to molybdenum as tridentate ONS-donors. Octahedral coordination of each molybdenum atom is completed by methanol molecule (in 1a-3a) or by oxygen atom of Mo=O unit from the neighbouring molecule (in 1-3). All complexes were characterized by means of chemical analyses, IR spectroscopy, TG and NMR measurements. The molecular structures of the ligand H2L2 and complex [MoO2L2(CH3OH)]• CH3OH (2a) have been determined by single crystal X-ray crystallography. The characterisation of thiosemicarbazonato molybdenum(VI) complexes (1-4) as well as of the 4-phenylthisemicarbazonato molybdenum(VI) complexes (5-8) in aqueous medium revealed that upon dissolving complexes in water, most likely to some extent dissociation took place, although experimental data didn’ t allow exact quantification of dissociation. The antiproliferative effects of studied molybdenum(VI) complexes (1-8) on the human cell lines were identical to the activity of their corresponding ligands.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Temeljne medicinske znanosti



POVEZANOST RADA

Projekti:
MZOS-098-0982464-2514 - Uloga različitih mehanizama odgovora stanica na terapiju oštećenjem DNA (Kralj, Marijeta, MZOS ) ( CroRIS)
MZOS-098-0982914-2918 - Dizajn, sinteza i ispitivanje interakcija malih molekula s DNA, RNA i proteinima (Piantanida, Ivo, MZOS ) ( CroRIS)
MZOS-119-1191342-1082 - Novi kompleksni spojevi i materijali-kemijski i biološki katalizatori (Cindrić, Marina, MZOS ) ( CroRIS)
MZOS-119-1191342-1083 - Interakcije i dizajn bioaktivnih molekula (Novak, Predrag, MZOS ) ( CroRIS)
MZOS-119-1193079-1084 - Strukturno istraživanje bioloških makromolekula metodom rentgenske difrakcije (Matković-Čalogović, Dubravka, MZOS ) ( CroRIS)

Ustanove:
Institut "Ruđer Bošković", Zagreb,
Prirodoslovno-matematički fakultet, Zagreb

Profili:

Avatar Url Ivo Piantanida (autor)

Avatar Url Sandra Kraljević Pavelić (autor)

Avatar Url Dubravka Matković-Čalogović (autor)

Avatar Url Andrea Rožman (autor)

Avatar Url Predrag Novak (autor)

Avatar Url Višnja Vrdoljak (autor)

Avatar Url Marijeta Kralj (autor)

Avatar Url Marina Cindrić (autor)

Avatar Url Ivica Đilović (autor)

Avatar Url Mirta Rubčić (autor)

Poveznice na cjeloviti tekst rada:

doi www.sciencedirect.com doi.org

Citiraj ovu publikaciju:

Vrdoljak, Višnja; Đilović, Ivica; Rubčić, Mirta; Kraljević Pavelić, Sandra; Kralj, Marijeta; Matković-Čalogović, Dubravka; Piantanida, Ivo; Novak, Predrag; Rožman, Andrea; Cindrić, Marina
Synthesis and characterization of thiosemicarbazonato molybdenum(VI) complexes and their in vitro antitumor activity // European journal of medicinal chemistry, 45 (2010), 1; 38-48 doi:10.1016/j.ejmech.2009.09.021 (međunarodna recenzija, članak, znanstveni)
Vrdoljak, V., Đilović, I., Rubčić, M., Kraljević Pavelić, S., Kralj, M., Matković-Čalogović, D., Piantanida, I., Novak, P., Rožman, A. & Cindrić, M. (2010) Synthesis and characterization of thiosemicarbazonato molybdenum(VI) complexes and their in vitro antitumor activity. European journal of medicinal chemistry, 45 (1), 38-48 doi:10.1016/j.ejmech.2009.09.021.
@article{article, author = {Vrdoljak, Vi\v{s}nja and \DJilovi\'{c}, Ivica and Rub\v{c}i\'{c}, Mirta and Kraljevi\'{c} Paveli\'{c}, Sandra and Kralj, Marijeta and Matkovi\'{c}-\v{C}alogovi\'{c}, Dubravka and Piantanida, Ivo and Novak, Predrag and Ro\v{z}man, Andrea and Cindri\'{c}, Marina}, year = {2010}, pages = {38-48}, DOI = {10.1016/j.ejmech.2009.09.021}, keywords = {thiosemicarbazone, molybdenum(VI) complexes, X-ray crystal structures, antiproliferative effects, tumour cell lines}, journal = {European journal of medicinal chemistry}, doi = {10.1016/j.ejmech.2009.09.021}, volume = {45}, number = {1}, issn = {0223-5234}, title = {Synthesis and characterization of thiosemicarbazonato molybdenum(VI) complexes and their in vitro antitumor activity}, keyword = {thiosemicarbazone, molybdenum(VI) complexes, X-ray crystal structures, antiproliferative effects, tumour cell lines} }
@article{article, author = {Vrdoljak, Vi\v{s}nja and \DJilovi\'{c}, Ivica and Rub\v{c}i\'{c}, Mirta and Kraljevi\'{c} Paveli\'{c}, Sandra and Kralj, Marijeta and Matkovi\'{c}-\v{C}alogovi\'{c}, Dubravka and Piantanida, Ivo and Novak, Predrag and Ro\v{z}man, Andrea and Cindri\'{c}, Marina}, year = {2010}, pages = {38-48}, DOI = {10.1016/j.ejmech.2009.09.021}, keywords = {thiosemicarbazone, molybdenum(VI) complexes, X-ray crystal structures, antiproliferative effects, tumour cell lines}, journal = {European journal of medicinal chemistry}, doi = {10.1016/j.ejmech.2009.09.021}, volume = {45}, number = {1}, issn = {0223-5234}, title = {Synthesis and characterization of thiosemicarbazonato molybdenum(VI) complexes and their in vitro antitumor activity}, keyword = {thiosemicarbazone, molybdenum(VI) complexes, X-ray crystal structures, antiproliferative effects, tumour cell lines} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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