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Pregled bibliografske jedinice broj: 425064

Evaluation of radioprotective effects of propolis and its flavonoid constituents: in vitro study on human white blood cells

Benković, Vesna; Horvat Knežević, Anica; Oršolić, Nada; Bašić, Ivan; Ramić, Snježana; Viculin, Tomislav; Knežević, Fabijan; Kopjar, Nevenka
Evaluation of radioprotective effects of propolis and its flavonoid constituents: in vitro study on human white blood cells // Phytoherapy Research, 23 (2009), 8; 1159-1168 doi:10.1002 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 425064 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Evaluation of radioprotective effects of propolis and its flavonoid constituents: in vitro study on human white blood cells

Autori
Benković, Vesna ; Horvat Knežević, Anica ; Oršolić, Nada ; Bašić, Ivan ; Ramić, Snježana ; Viculin, Tomislav ; Knežević, Fabijan ; Kopjar, Nevenka

Izvornik
Phytoherapy Research (0951-418X) 23 (2009), 8; 1159-1168

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
propolis; flavonoids; radioprotection; in vitro; leukocytes

Sažetak
This in vitro study aims at evaluating the possible radioprotective effects of natural substances WSDP, caffeic acid, chrysin and naringin on γ -irradiated human white blood cells. The effectiveness of tested compounds was evaluated using the alkaline comet assay, the analysis of structural chromosome abberation and cytokinesis-block micronucleus assay. The results obtained by alkaline comet study indicate favorable toxicity profiles of propolis and its polyphenolic components, and confirmed radioprotective abilities comparable with chemical radioprotector AET. WSDP and its polyphenolic components were able to reduce the number of necrotic cells. None of tested compounds induced significant genotoxicity evens all of them offered a quite measurable protection against DNA damage. WSDP was found to be most effective in diminishing the levels of primary and more complex cytogenetic DNA damage in white blood cells. Considering its complex composition, to undoubtedly explain the underlying mechanisms of cyto/radioprotective effects, further studies are needed.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija



POVEZANOST RADA

Projekti:
022-0222148-2137 - Genotoksičnost kemijskih i fizikalnih agensa prirodnog i antropogenog podrijetla (Kašuba, Vilena, MZOS ) ( CroRIS)
119-0000000-1255 - Kemoprevencija rasta tumora polifenolnim sastavnicama (Oršolić, Nada, MZOS ) ( CroRIS)
119-0532265-1254 - Imunoadjuvantno i zaštitno djelovanje propolisa u životinja (Benković, Vesna, MZOS ) ( CroRIS)

Ustanove:
Institut za medicinska istraživanja i medicinu rada, Zagreb,
Prirodoslovno-matematički fakultet, Zagreb

Profili:

Avatar Url Tomislav Viculin (autor)

Avatar Url Vesna Benković (autor)

Avatar Url Anica Horvat Knežević (autor)

Avatar Url Snježana Ramić (autor)

Avatar Url Ivan Bašić (autor)

Avatar Url Nada Oršolić (autor)

Avatar Url Nevenka Kopjar (autor)

Avatar Url Fabijan Knežević (autor)

Poveznice na cjeloviti tekst rada:

doi

Citiraj ovu publikaciju:

Benković, Vesna; Horvat Knežević, Anica; Oršolić, Nada; Bašić, Ivan; Ramić, Snježana; Viculin, Tomislav; Knežević, Fabijan; Kopjar, Nevenka
Evaluation of radioprotective effects of propolis and its flavonoid constituents: in vitro study on human white blood cells // Phytoherapy Research, 23 (2009), 8; 1159-1168 doi:10.1002 (međunarodna recenzija, članak, znanstveni)
Benković, V., Horvat Knežević, A., Oršolić, N., Bašić, I., Ramić, S., Viculin, T., Knežević, F. & Kopjar, N. (2009) Evaluation of radioprotective effects of propolis and its flavonoid constituents: in vitro study on human white blood cells. Phytoherapy Research, 23 (8), 1159-1168 doi:10.1002.
@article{article, author = {Benkovi\'{c}, Vesna and Horvat Kne\v{z}evi\'{c}, Anica and Or\v{s}oli\'{c}, Nada and Ba\v{s}i\'{c}, Ivan and Rami\'{c}, Snje\v{z}ana and Viculin, Tomislav and Kne\v{z}evi\'{c}, Fabijan and Kopjar, Nevenka}, year = {2009}, pages = {1159-1168}, DOI = {10.1002}, keywords = {propolis, flavonoids, radioprotection, in vitro, leukocytes}, journal = {Phytoherapy Research}, doi = {10.1002}, volume = {23}, number = {8}, issn = {0951-418X}, title = {Evaluation of radioprotective effects of propolis and its flavonoid constituents: in vitro study on human white blood cells}, keyword = {propolis, flavonoids, radioprotection, in vitro, leukocytes} }
@article{article, author = {Benkovi\'{c}, Vesna and Horvat Kne\v{z}evi\'{c}, Anica and Or\v{s}oli\'{c}, Nada and Ba\v{s}i\'{c}, Ivan and Rami\'{c}, Snje\v{z}ana and Viculin, Tomislav and Kne\v{z}evi\'{c}, Fabijan and Kopjar, Nevenka}, year = {2009}, pages = {1159-1168}, DOI = {10.1002}, keywords = {propolis, flavonoids, radioprotection, in vitro, leukocytes}, journal = {Phytoherapy Research}, doi = {10.1002}, volume = {23}, number = {8}, issn = {0951-418X}, title = {Evaluation of radioprotective effects of propolis and its flavonoid constituents: in vitro study on human white blood cells}, keyword = {propolis, flavonoids, radioprotection, in vitro, leukocytes} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

Uključenost u ostale bibliografske baze podataka::


  • EMBASE (Excerpta Medica)

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