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Pregled bibliografske jedinice broj: 422005

Liposome fusogenicity and entrapment efficiency of antigen determine the Th1/Th2 bias of antigen-specific immune response

Brgles, Marija; Habjanec, Lidija; Halassy, Beata; Tomašić, Jelka
Liposome fusogenicity and entrapment efficiency of antigen determine the Th1/Th2 bias of antigen-specific immune response // Vaccine, 27 (2009), 40; 5435-5442 doi:10.1016/j.vaccine.2009.07.012 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 422005 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Liposome fusogenicity and entrapment efficiency of antigen determine the Th1/Th2 bias of antigen-specific immune response

Autori
Brgles, Marija ; Habjanec, Lidija ; Halassy, Beata ; Tomašić, Jelka

Izvornik
Vaccine (0264-410X) 27 (2009), 40; 5435-5442

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Cationic liposomes; Adjuvants; Entrapment efficiency; Th bias

Sažetak
Liposomes, either alone or in combination with additional immunostimulatory molecules, could be used for delivery of antigens as vaccine adjuvants. The aim of this study was to investigate the influence of ; a) composition (fusogenicity and charge) of large multilamellar liposomes, b) antigen entrapment efficiency into cationic liposomes and c) addition of immunostimulatory peptidoglycan monomer (PGM) into liposomal formulations on intensity and direction of antigen-specific humoral immune response. Ovalbumin (OVA) was used as a model antigen and liposomal formulations were tested in a well defined experimental mice model. It was shown that, by means of controlling ionic strength of the media, entrapment efficiency of OVA was enhanced and this lead to Th1 biased immune response. Also, by varying liposome composition and increasing fusogenicity of liposomes immune response was directed toward Th1. Addition of immunostimulatory PGM into liposomal formulation resulted in a switch toward Th2 type immune response.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija, Temeljne medicinske znanosti



POVEZANOST RADA

Projekti:
021-0212432-2033 - Imunogeničnost komponenti kompleksnih antigena (Halassy, Beata, MZOS ) ( CroRIS)
021-0212432-2431 - Nove formulacije antigena i imunostimulatora - utjecaj na imunoreakciju (Frkanec, Ruža, MZOS ) ( CroRIS)

Ustanove:
Imunološki zavod d.d.

Profili:

Avatar Url Jelka Tomašić (autor)

Avatar Url Marija Brgles (autor)

Avatar Url Lidija Habjanec (autor)

Avatar Url Beata Halassy (autor)

Poveznice na cjeloviti tekst rada:

doi www.sciencedirect.com

Citiraj ovu publikaciju:

Brgles, Marija; Habjanec, Lidija; Halassy, Beata; Tomašić, Jelka
Liposome fusogenicity and entrapment efficiency of antigen determine the Th1/Th2 bias of antigen-specific immune response // Vaccine, 27 (2009), 40; 5435-5442 doi:10.1016/j.vaccine.2009.07.012 (međunarodna recenzija, članak, znanstveni)
Brgles, M., Habjanec, L., Halassy, B. & Tomašić, J. (2009) Liposome fusogenicity and entrapment efficiency of antigen determine the Th1/Th2 bias of antigen-specific immune response. Vaccine, 27 (40), 5435-5442 doi:10.1016/j.vaccine.2009.07.012.
@article{article, author = {Brgles, Marija and Habjanec, Lidija and Halassy, Beata and Toma\v{s}i\'{c}, Jelka}, year = {2009}, pages = {5435-5442}, DOI = {10.1016/j.vaccine.2009.07.012}, keywords = {Cationic liposomes, Adjuvants, Entrapment efficiency, Th bias}, journal = {Vaccine}, doi = {10.1016/j.vaccine.2009.07.012}, volume = {27}, number = {40}, issn = {0264-410X}, title = {Liposome fusogenicity and entrapment efficiency of antigen determine the Th1/Th2 bias of antigen-specific immune response}, keyword = {Cationic liposomes, Adjuvants, Entrapment efficiency, Th bias} }
@article{article, author = {Brgles, Marija and Habjanec, Lidija and Halassy, Beata and Toma\v{s}i\'{c}, Jelka}, year = {2009}, pages = {5435-5442}, DOI = {10.1016/j.vaccine.2009.07.012}, keywords = {Cationic liposomes, Adjuvants, Entrapment efficiency, Th bias}, journal = {Vaccine}, doi = {10.1016/j.vaccine.2009.07.012}, volume = {27}, number = {40}, issn = {0264-410X}, title = {Liposome fusogenicity and entrapment efficiency of antigen determine the Th1/Th2 bias of antigen-specific immune response}, keyword = {Cationic liposomes, Adjuvants, Entrapment efficiency, Th bias} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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