Naslov
Aseptic meningitis, sensorineural hearing loss induced by simultaneous use of ibuprofen and ciprofloxacin

Autori
Sepčić, Juraj ; Materljan, Eris ; Šepić Grahovac, Dubravka ; Jurjević, Ante

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
Acta Neuropsychiatrica. Proceedings. 49 th International Neuropsychiatric Pula Congress (INPC) / Vida Demarin, Vanja Bašić Kes, Zlatko Trkanjec - : Wiley-Blackwell, 2009

Skup
49 th International Neuropsychiatric Pula Congress (INPC)

Mjesto i datum
Pula, Hrvatska, 17.06.2009. - 20.06.2009

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Aseptic meningitis; sensorineural hearing loss; ibuprofen; ciprofloxacin

Sažetak
Aseptic meningitis (AM), with or without other drug-induced neurological disorders, has been the subject of several reviews. We report clinically rare and serious adverse reactions that occurred after the co-administration of Ibuprofen and Ciprofloxacin: completely reversible aseptic meningitis and irreversible bilateral hearing loss, tinnitus , and vestibulopathy. Recurrent urinary inflammation treated with antibiotics, classic migraine, and allergy to trimethoprim-sulfamethoxazole and chromium were favorable predisposing factors for the adverse event in this patient. A close chronological relation between administration of drugs (especially Ibuprofen) and adverse reactions was noted. No evidence of infection and/or autoimmune disease was found. The mechanism of these serious events may be explained as a hypersensitive reaction affecting the meanings and, partially, cochlea.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti, Farmacija

POVEZANOST RADA