Naslov
Sex-related expression of renal organic anion and cation transporters in different species

Autori
Sabolić, Ivan ; Ljubojević, Marija ; Breljak, Davorka ; Balen, Daniela ; Brzica, Hrvoje ; Micek, Vedran ; Radović, Nikola ; Kraus, Ognjen

Vrsta, podvrsta i kategorija rada
Radovi u zbornicima skupova, cjeloviti rad (in extenso), znanstveni

Izvornik
Proceedings of the International Scientific Meeting of Anatomy and Physiology ; Fundamentals of Medicine / Mihelić, Damir ; Šimpraga, Miljenko ; Tkalčić, Suzana - Zagreb : Medicinska naklada, 2009, 33-40

ISBN
978-953-6062-72-0

Skup
The International Scientific Meeting of Anatomy and Physiology ; Fundamentals of Medicine

Mjesto i datum
Zagreb, Hrvatska, 12.06.2009. - 13.06.2009

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Nije recenziran

Ključne riječi
gender differences; human; kidney; mouse; organic compounds; pig; rat

Sažetak
In the mammalian kidney, transport of endogenous and xenobiotic organic compounds is mediated by multispecific organic anion and cation transporters localized in the apical and basolateral cell membrane domains of the specific nephron segments. These transporters are also responsible for drug resistance, drug-drug interactions, and drug-induced nephrotoxicity. In rat and mouse proximal tubules, a number of these transporters exhibit sex differences in their expression. In comparison with those in rodents, in pig and human proximal tubules some transporters are absent, some exhibit different localization in the cell membrane domains, and none exhibits the sex-dependent expression. These differences indicate that: a) the data on renal transporters in one species can not simply be regarded as relevant for other species, and b) pigs may be better model then rodents for drug-related studies relevant to humans.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA