Pregled bibliografske jedinice broj: 419399
Dichotomy of NF-kB and TGF-beta signaling pathways likely underly dual edges sword nature of cytokines primed microglia activation in the course of brain repair reaction
Dichotomy of NF-kB and TGF-beta signaling pathways likely underly dual edges sword nature of cytokines primed microglia activation in the course of brain repair reaction // Abstract Book of Keystone Symposia on Molecular and Cellular Biology of NF-kB, Fairmont Banff, Springs, Alberta Canada, February 12-17, 2008 / Vishva M.Dixit, Shao-Cong Sun and Sankar Ghosh (ur.).
Silverthorne (CO), 2008. str. 77-77 (poster, međunarodna recenzija, sažetak, znanstveni)
CROSBI ID: 419399 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Dichotomy of NF-kB and TGF-beta signaling pathways likely underly dual edges sword nature of cytokines primed microglia activation in the course of brain repair reaction
Autori
Poljak, Ljiljana
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
Abstract Book of Keystone Symposia on Molecular and Cellular Biology of NF-kB, Fairmont Banff, Springs, Alberta Canada, February 12-17, 2008
/ Vishva M.Dixit, Shao-Cong Sun and Sankar Ghosh - Silverthorne (CO), 2008, 77-77
Skup
Keystone symposia on Molecular and cellular Biology of NF-kB
Mjesto i datum
Banff, Kanada, 12.02.2008. - 17.02.2008
Vrsta sudjelovanja
Poster
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
NF-kB signaling; microglia; brain repair
(NF-kB signaling; Microglia; brain repair)
Sažetak
Microglial cells are considered to be the most responsive cells of Central Nervous System (CNS) to the action of immune effector molecules. When cytokines primed microglia becomes activated this may be either beneficial or deleterious for injured brain depending on the type of priming. Since JAK-1 is not just an important mediator of cytokine signaling but also critical for regulation of the intrinsic responsivness of neural progenitors to astrogliogenic factors, we have performed transfection experiments on cells genetically modified for Jak-1.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti
