Naslov
Reproductive toxicity of atrazine given in vivo to female rats

Autori
Kniewald, Jasna ; Tomljenović, Andrea ; Kniewald, Zlatko

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
XXXVI European Cogress of Toxicology - EUROTOX"97 Pharmacology & Toxicology, Volume 80, Supplement III, 1997 / The Danish Society of Pharmacology and Toxicology - Aarhus : Munksgaard, 1997

Skup
XXXVI European Cogress of Toxicology - EUROTOX"97

Mjesto i datum
Århus, Danska, 25.06.1997. - 28.06.1997

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
atrazine; female rat; immunohistochemistry; estrogen receptor

Sažetak
The effect of 2-chloro-4-ethylamino-6-isopropylamino-s-triazine (atrazine, A) has been examined on the rat basal hypothalamus (H), pituitary (P), ovaries (O) and uterus (U). Immunohistichemical detection and quantitative evaluation of LH, FSH or estrogen receptor positive cells have shown significant effects of A in all examined tissues. Adult virgin females Wistar rats 100 days old were used in study. LH and FSH have been in P of control rats from 15-23% higher than in A treated. LH secreted from P was located at oocyte in O of control rats. Three days A treated rats (120 mg/kg b.w.) had regular estrus cycle and oocytes with a lot of LH, but seven days treated rats were in permanent diestrus and did not develop a mature oocyte. Estrogen receptor positive cells in U dependent upon of phase of cycle. After A treatment (our published results, Fd Chem Toxic, 1992) the number of binding sites in U cytosol for estradiol receptors have beeen reduced for 14-40.5%. Estrogen receptor positive cells in this study are reduced 23.5%. It probably leads to decrease production of mRNA and some proteins coded by genes in rat uterus. Supported by Ministry S&T Croatia and PLIVA dd.

Izvorni jezik
Engleski

Znanstvena područja
Prehrambena tehnologija

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