Naslov
Effects of chronic dietary exposure to a low-dose of Malathion, Aroclor-1254 and 3-methylcholanthrene on three biomarkers in male mice

Autori
Hackenberger Kutuzović, Branimir ; Jarić, Davorka ; Hackenberger, Dubravka ; Stepić, Sandra

Izvornik
Acta biologica hungarica (0236-5383) 61 (2010), 4; 423-433

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
malathion; 3-methylcholanthrene; Aroclor-1254; biomarker; mice

Sažetak
The aim of this research was to examine the applicability of some chronic toxicological tests in determination of exposure to xenobiotics present in concentrations below No Observed Adverse Effect Level (NOAEL) and below the detection limit of analytical instruments. In the present experiment tested chemicals (Malathion, Aroclor-1254 and 3-methylcholanthrene (3-MC)) were mixed with wheat grains and given to male mice as feed over a period of 12 months. 7-ethoxyresorufin-O-deethylase (EROD) activity with the 3-MC and Aroclor-1254 treatments reached the peak at 9th month of exposure (26.7 and 42.4 pmol-1mgprot-1, respectively), while malathion didn’t have significant influence. Glutathione (GSH) level depletion was highest after three months of exposure. Unexpectedly, acetylcholinesterase (AChE) activity increased under malathion, an organophosphorous insecticide, treatment. In conclusion, low-level concentrations chronically administered exert certain effects on the levels of selected enzymes e.g. biomarkers.

Izvorni jezik
Engleski

Znanstvena područja
Biologija

POVEZANOST RADA