Naslov
Variants of ESR1, APOE, LPL and IL-6 loci in young healthy subjects: association with lipid status and obesity

Autori
Sertić, Jadranka ; Juričić, Ljiljana ; Ljubić, Hana ; Božina, Tamara ; Lovrić, Jasna ; Markeljević, Jasenka ; Jelaković, Bojan ; Merkler, Marijan ; Reiner, Željko

Izvornik
BMC research notes (1756-0500) 2 (2009); 203-210

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, kratko priopcenje, znanstveni

Ključne riječi
ESR1 ; APOE ; LPL ; IL-6 gene variants ; young healthy subjects ; obesity

Sažetak
Human obesity is a multifactorial syndrome influenced by both environmental and genetic factors. We explored the association of genetic polymorphisms of: estrogen receptor alpha (ESR1-TA repeats) ; interleukin-6 (IL-6 G-174C) ; apolipoprotein E (APO e2, e3, e4) ; lipoprotein lipase Pvu II (LPL P+/-) with clinical variables: gender, age, body mass index (BMI), diet type and biological variables: triglycerides, cholesterol, HDL, LDL, CRP, homocysteine, urate, and glucose in 105 healthy young subjects (20-35 yrs) of Croatian origin. ESR1, LPL and APO E genetic polymorphic variants could represent predictive genetic risk markers for obesity-related metabolic disorders in young healthy subjects. Mediterranean type of diet is also an important positive factor in abdominal obesity.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA