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Pregled bibliografske jedinice broj: 409457

Polyploidy in early spontaneous abortions


Tonković Ð urišević, I; Mužinić, D; Lasan, R; Crkvenac Gornik, K; Letica, L; Burek, M; Begović, D
Polyploidy in early spontaneous abortions // ESHG
Barcelona, Španjolska, 2008. (poster, međunarodna recenzija, sažetak, stručni)


CROSBI ID: 409457 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Polyploidy in early spontaneous abortions

Autori
Tonković &ETH ; urišević, I ; Mužinić, D ; Lasan, R ; Crkvenac Gornik, K ; Letica, L ; Burek, M ; Begović, D

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
ESHG / - , 2008

Skup
European HUMAN GENETICS Conference 2008

Mjesto i datum
Barcelona, Španjolska, 31.05.2008. - 03.06.2008

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Poliploidy; spontaneous abortions

Sažetak
Polyploidy is a condition in which there is more than two sets of chromosomes. A total of 321 cases of first trimester spontaneous abortions between 4 and 13 weeks of gestation were analyzed cytogenetically by direct - preparation method using chorionic villi. Among 54% of abnormal karyotypes, trisomy was predominant. The second most common abnormality was triploidy found in 25 (7, 8%) cases. Triploidy may arise from fertilization of haploid egg by two haploid sperm or by maternal or paternal meiotic errors. Tetrapoidy is a rare ploidy abnormality and was detected in 3 (0, 9%) cases, 92, XXYY and 92, XXXX sex chromosome complement. Among the triploid abortions the gonosomal constitution of XXY prevailed (14 cases), followed by XXX (8cases) and XYY (3 cases). The maternal age ranged from 18 to 35 age and the gestational age from 6 to 13 weeks. In this study the frequency of poliploidy abortions decreased with maternal age, what confirms that increased maternal age is not a risk factor and mechanism of poliploidy. Triploidy and tetraploidy together account for 18% of chromosomal abnormalities and give rise to a significant proportion of human pregnancy wastage. Poliploidyies are numerical abnormalities, are sporadic, and they do not usually recur in subsequent pregnancies.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekti:
108-0000000-0353 - Novi pristupi dijagnostici nasljednih bolesti (Begović, Davor, MZOS ) ( CroRIS)

Ustanove:
Medicinski fakultet, Zagreb


Citiraj ovu publikaciju:

Tonković Ð urišević, I; Mužinić, D; Lasan, R; Crkvenac Gornik, K; Letica, L; Burek, M; Begović, D
Polyploidy in early spontaneous abortions // ESHG
Barcelona, Španjolska, 2008. (poster, međunarodna recenzija, sažetak, stručni)
Tonković Ð, urišević, I., Mužinić, D., Lasan, R., Crkvenac Gornik, K., Letica, L., Burek, M. & Begović, D. (2008) Polyploidy in early spontaneous abortions. U: ESHG.
@article{article, author = {uri\v{s}evi\'{c}, I and Mu\v{z}ini\'{c}, D and Lasan, R and Crkvenac Gornik, K and Letica, L and Burek, M and Begovi\'{c}, D}, year = {2008}, keywords = {Poliploidy, spontaneous abortions}, title = {Polyploidy in early spontaneous abortions}, keyword = {Poliploidy, spontaneous abortions}, publisherplace = {Barcelona, \v{S}panjolska} }
@article{article, author = {uri\v{s}evi\'{c}, I and Mu\v{z}ini\'{c}, D and Lasan, R and Crkvenac Gornik, K and Letica, L and Burek, M and Begovi\'{c}, D}, year = {2008}, keywords = {Poliploidy, spontaneous abortions}, title = {Polyploidy in early spontaneous abortions}, keyword = {Poliploidy, spontaneous abortions}, publisherplace = {Barcelona, \v{S}panjolska} }




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