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Pregled bibliografske jedinice broj: 408303

Protection of acetaminophen-induced hepatotoxicity in mice by PGE2


Renić, Marija; Čulo, Filip, Bilić, Ante, Čuljak, Krizan, Sabolović, Domagoj; Jagić, Vjekoslav
Protection of acetaminophen-induced hepatotoxicity in mice by PGE2 // The Croatian journal of gastroenterology and hepatology, 1 (1992), 1; 59-64 (podatak o recenziji nije dostupan, članak, ostalo)


CROSBI ID: 408303 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Protection of acetaminophen-induced hepatotoxicity in mice by PGE2

Autori
Renić, Marija ; Čulo, Filip, Bilić, Ante, Čuljak, Krizan, Sabolović, Domagoj ; Jagić, Vjekoslav

Izvornik
The Croatian journal of gastroenterology and hepatology (0353-9296) 1 (1992), 1; 59-64

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, ostalo

Ključne riječi
Prostaglandins E; Acetaminophen; Hepatitis; Toxic

Sažetak
Acetaminophen (AAP) administered to mice via gastric tube in a dose of 300-350 mg/kg induced heavy liver injury and killed 55% - 80% mice within 48 hours. Dimethyl-16-16 prostaglandin E2 (PGE2), given intraperitoneally (0.025-0.2 mg/kg) 15 to 30 minutes before AAP, ameliorated the liver injury and reduced the mortality in mice to 20%-30%. PGE2 also significantly reduced the increase in plasma transaminase (ALT, AST) levels induced by AAP. In the same doses, PGE1 had a slight but not significantly protective effect. When given 2 hours after AAP administration, PGE2 delayed the death of mice but had no significant effect on total mortality. Pretreatment of mice with indomethacin (4 mg/kg i.p.) had no effect on AAP toxicity, while pretreatment of mice with specific anti-PGE2 antibodies increased this toxicity. Thus, PGE2 was concluded to have a protective role in AAP-induced hepatotoxicity.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekti:
0108064
0108058

Ustanove:
Medicinski fakultet, Zagreb

Profili:

Avatar Url Vjekoslav Jagić (autor)

Avatar Url Filip Čulo (autor)

Avatar Url Marija Renić (autor)

Poveznice na cjeloviti tekst rada:

Pristup cjelovitom tekstu rada

Citiraj ovu publikaciju:

Renić, Marija; Čulo, Filip, Bilić, Ante, Čuljak, Krizan, Sabolović, Domagoj; Jagić, Vjekoslav
Protection of acetaminophen-induced hepatotoxicity in mice by PGE2 // The Croatian journal of gastroenterology and hepatology, 1 (1992), 1; 59-64 (podatak o recenziji nije dostupan, članak, ostalo)
Renić, M., Čulo, Filip, Bilić, Ante, Čuljak, Krizan, Sabolović, Domagoj & Jagić, V. (1992) Protection of acetaminophen-induced hepatotoxicity in mice by PGE2. The Croatian journal of gastroenterology and hepatology, 1 (1), 59-64.
@article{article, author = {Reni\'{c}, Marija and Jagi\'{c}, Vjekoslav}, year = {1992}, pages = {59-64}, keywords = {Prostaglandins E, Acetaminophen, Hepatitis, Toxic}, journal = {The Croatian journal of gastroenterology and hepatology}, volume = {1}, number = {1}, issn = {0353-9296}, title = {Protection of acetaminophen-induced hepatotoxicity in mice by PGE2}, keyword = {Prostaglandins E, Acetaminophen, Hepatitis, Toxic} }
@article{article, author = {Reni\'{c}, Marija and Jagi\'{c}, Vjekoslav}, year = {1992}, pages = {59-64}, keywords = {Prostaglandins E, Acetaminophen, Hepatitis, Toxic}, journal = {The Croatian journal of gastroenterology and hepatology}, volume = {1}, number = {1}, issn = {0353-9296}, title = {Protection of acetaminophen-induced hepatotoxicity in mice by PGE2}, keyword = {Prostaglandins E, Acetaminophen, Hepatitis, Toxic} }

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