Naslov
DNA methylation status during mouse experimental teratocarcinoma development

Autori
Sinčić, Nino ; Vlahović, Maja ; Herceg, Zdenko ; Šerman, Ljiljana ; Paić, Frane ; Katušić, Ana, Bulić-Jakuš, Floriana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo

Izvornik
Conference papers of 20th Ljudevit Jurak International Symposium on Comparative Pathology / - Zagreb, 2009, 14-14

Skup
20th Ljudevit Jurak International Symposium on Comparative Pathology

Mjesto i datum
Zagreb, Hrvatska, 05.06.2009. - 06.06.2009

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
teratocarcinoma; mouse; DNA methylation

Sažetak
The aim of this study was to determine DNA methylation pattern of genes involved in teratocarcinoma development: pluripotency and self-renewal genes Oct4, Sox2 and Nanog, as well as Brca1, Stat3, PRSS21 and SCGB3a1 genes in completely developed teratocarcinoma and embryo. We observed that DNA methylation of transcription factor and tumor-suppressor genes is not involved in embryonal cells transformation/progression of experimental teratocarcinoma, but core transcriptional regulatory circuitry genes seem to be crucial for teratocarcinoma development.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA