Naslov
How Many H. pylori Positive Patients Can Be Eradicated with Two Consecutive Regimens Proposed by the Maastricht Consensus Rules?

Autori
Katicic, Miroslava ; Filipec-Kanizaj, Tajana ; Mrzljak, Anna ; Prskalo, Marija ; Ticak, Mirjana ; Skurla, Bruno ; Naumovski-Mihalic, Slavica Sabaric, Branka ; Colic-Cvrlje, Vesna

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Helicobacter. 13(5):460, October 2008. Helicobacter / Graham, David, J - Houston (TX) : Wiley-Blackwell, 2008, 460-460

Skup
XXI International Workshop on Helicobacter and related bacteria in chronic digestive inflammation

Mjesto i datum
Riga, Latvija, 18.09.2008. - 20.09.2008

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Helicobacter; Maastricht consensus

Sažetak
Background: All three Maastricht Consensuses suggest same drags combination for treatment H.pylori infection ; proton pump inhibitor(PPI) and two of three antibiotics: Amoxicillin(A), Clarithromycin(C), Metronidazole(M), and for resistant H.pylori strains quadruple regimen consisting of PPI, Bismuth(B), M and Tetracycline(T).From 1996 we treated our patients according this suggestion. Aim: To calculate H. pylori eradication rates which can be achieved by such two steps of treatment regimens. Methods: 1067 consecutive H.pylori positive patients received first one of three regimens(PPI+C+M, PPI+A+C, PPI+A+M) ; during second treatment we replaced M with C, and vice versa or used quadruple regimen(PPI+B+M+T). Success rate was calculated by intention to treat(ITT) and per protocol(PP) analyses. H.pylori eradication was assessed by histology or UBT. Results: After first treatment 797 patients were eradicated and 18 patients were lost (ITT-74.7%, PP-76, 0% ; ) ; Eradication rate with PPI+M+C was 78, 9%, with PPI+A+C 76, 0%, and with PPI+A+M 74, 1%. Remaining 252 H.pylori+ve patients were treated according above task. Infection was eradicated in 142 patients and 40 patients were lost. (ITT-56, 3%, PP-67, 0%). Eradication was achieved with PPI+M+C in 68, 2%, with PPI+A+C in 69, 9%, with PPI+A+M in 60, 0%, and with PPI+B+M+T in 84, 2%. Summary, from 1067 patients included in treatment we eradicated H.pylori infection in 997 patients, lost from study 58 patients, and 70 patients remained positive (ITT-88, 0% ; PP-93, 4%). Primary resistance to clarithromycin was 8.4 % and for metronidazol 33.5 %. Conclusion: Two consecutive treatments proposed by all three Maastricht consensuses, achieved enough high H.pylori eradication rates in Republic Croatia with still relative low primary resistance to Clarithromycin.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA