Naslov
Systemic administration of bone morphogenetic proteins

Autori
Vukičević, Slobodan ; Šimić, Petra ; Grgurević, Lovorka ; Borovečki, Fran ; Sampath, Kuber

Vrsta, podvrsta i kategorija rada
Poglavlja u knjigama, znanstveni

Knjiga
Bone Morphogenetics Proteins: From Local to Systemic Therapeutics

Urednik/ci
Vukičević, Slobodan ; Sampath, Kuber

Izdavač
Birkhäuser

Grad
Basel : Boston : Berlin

Godina
2008

Raspon stranica
317-338

ISBN
3764385510

Ključne riječi
bone morphogenetic proteins, osteoporosis, renal failure

Sažetak
Tissue engineering is gaining interest as it is applied for regeneration of organs to attain their lost function. Although resorbable scaffolds and progenitor cell types are required principles to engineer a functional tissue locally, the inductive signal is a prerequisite to trigger the growth and differentiation of responding cells in space and time. Bone morphogenetic proteins (BMPs), also called growth and differentiation factors (GDFs), originally identified from bone have been successfully used to regenerate the bone in humans. Most recent preclinical data suggests that BMPs have a potential to provide protection against inflammation and fibrosis in acute and chronic injury of parenchymal tissues when applied systemically to sustain the function of kidney and liver. The application of BMPs from a local to systemic utility is a rapidly growing field, gaining interest among researchers and biotech entrepreneurs.

Izvorni jezik
Engleski

POVEZANOST RADA