ࡱ> :<9q` 0+"bjbjqPqP .*::D 2ikkkkkk$@h9 2i i    @] uN F M0 ,    FdF  POLYMORPHISMS OF PARAOXONASE GENES AS A GENETIC RISK FACTOR IN PERIPHERAL ATHEROSCLEROSIS Z. Flegar- Meatri1, M.M. Kardum Paro1, S. Perkov1, V. Vidjak2, K. Nova i2, M. Grdi3, D. Jureti3, K. Bariai3 1 Institute of Clinical Chemistry and 2 Institute for Radiology University Hospital Merkur, 3 Faculty of Pharmacy and Medical Biochemistry University of Zagreb, Zagreb, Croatia E-mail:  HYPERLINK "mailto:zlata.mestric@zg.t-com.hr" zlata.mestric@zg.t-com.hr Background. The most common polymorphisms in the coding (Q192R and L55M) and in the promoter region (-108C>T) of pon1 gene, as well as S311C polymorphism of pon2 gene, influence the enzyme anti-oxidant capacity and could be one of the genetic risk factors for the development of atherosclerosis. The aim of study was to examine the polymorphisms of pon1 and pon2 genes in patients with peripheral atherosclerosis. Methods. DNA was extracted from peripheral blood leukocytes (30 controls and 30 patients with peripheral atherosclerosis) and used for amplification by polymerase chain reaction (PCR) and restriction analysis. Differences in genotypes distribution were tested by Fischer2 s exact test or Chi square test. Results. Genotype frequencies of pon1 and pon2 genes polymorphisms founded in cases vs. controls were: 21 (0,70) QQ, 9 (0,30) QR, 0 (0,00) RR vs. 15 (0,50) QQ, 13 (0,43) QR, 2 (0,07) RR for Q192R; 11 (0,37) LL, 14 "$<Fx տլ{{kYE4 hLEwhCJOJQJ^JaJ&hLEwh>*CJH*OJQJ^JaJ#hLEwh>*CJOJQJ^JaJhcMh5CJOJQJaJh N5CJOJQJaJhcMh N5CJOJQJaJ&hcMh N5CJOJQJ\^JaJ%h NCJOJQJ]^JaJmH sH +hcMh NCJOJQJ]^JaJmH sH 1h Nh N5CJOJQJ\]^JaJmH sH "h Nh N5CJOJQJ\aJ u T*"+"gd5gd)gdcMgd  p#gdLEwgd Ngd{ +"    4 6 : N P R T d f ~ - / ˹˨ܖpW1jhcMhCJOJQJU^JaJmHsH(hcMhCJOJQJ^JaJmHsH hcMhCJOJQJ^JaJ#hcMhCJH*OJQJ^JaJ hLEwhLEwCJOJQJ^JaJ#hLEwhCJH*OJQJ^JaJ hLEwhCJOJQJ^JaJ hLEwhCJOJQJ^JaJ#hLEwhCJH*OJQJ^JaJ ; E H ϶|fPf;f(hcMhxCJOJQJ^JaJmH sH +hcMh)CJOJQJ]^JaJmH sH +hcMhxCJOJQJ]^JaJmH sH .hcMhx5CJOJQJ]^JaJmH sH hcMh"-CJaJ,hcMh0JCJOJQJ^JaJmHsH1jhcMhCJOJQJU^JaJmHsH7jhcMhCJOJQJU^JaJmHsH(hcMhCJOJQJ^JaJmHsH H L t x   " 4 8 = A d s t u } ~ ҿufR@#hcMh)CJOJQJ]^JaJ&hcMhm5CJOJQJ]^JaJhcMCJOJQJ]^JaJ#hcMh5CJOJQJ]^JaJ&hcMhm6CJOJQJ]^JaJ#hcMhJCJOJQJ]^JaJ#hcMhmCJOJQJ]^JaJ%hcMCJOJQJ]^JaJmH sH +hcMhxCJOJQJ]^JaJmH sH .hcMhx6CJOJQJ]^JaJmH sH RTd "*26>DLPX^fjx         # % ͻU#hcMhqCJOJQJ]^JaJ#hcMh4 CJOJQJ]^JaJ&hcMh"-6CJOJQJ]^JaJ#hcMh"-CJOJQJ]^JaJ&hcMh"-5CJOJQJ]^JaJhcMCJOJQJ^JaJ hcMh)CJOJQJ^JaJ2(0,47) LM, 5 (0,16) MM vs. 11 (0,37) LL, 15 (0,50) LM, 4 (0,13) MM for L55M; 0 (0,00) CC, 15 (0,50) CS, 15 (0,50) SS vs. 1 (0,04) CC, 13 (0,43) CS, 16 (0,53) SS for S311C and 16 (0,55) CC, 5 (0,17) CT, 8 (0,28) TT vs. 11 (0,37) CC, 17 (0,57) CT, 2 (0,06) TT for -108C>T. Conclusions. There was no significant difference in distribution of Q192R (p =0,187), L55M (p = 0,929) or S311C genotypes (p = 1,000), but significant difference in distribution of -108C>T genotype (p = 0,004) between patients with peripheral atherosclerosis and controls was found. % ) - 1 3 7 : > @ M P T V Z ^ b d h l p r y | !!!ɵ#hcMhY3CJOJQJ]^JaJ&hcMhY35CJOJQJ]^JaJ#hcMhfE CJOJQJ]^JaJ#hcMhqCJOJQJ]^JaJ#hcMh4 CJOJQJ]^JaJ;!'!o!p!q!t!!!!!!!!"""")"*"۸o]L; hcMh\?CJOJQJ^JaJ hcMheUCJOJQJ^JaJ#hcMheUCJOJQJ]^JaJ#hcMh5CJOJQJ]^JaJ hcMhvCJOJQJ^JaJ hcMhCJOJQJ^JaJ(hcMhACJOJQJ^JaJmH sH  hcMhY3CJOJQJ^JaJ#hcMhvCJOJQJ]^JaJ#hcMhY3CJOJQJ]^JaJ#hcMhCJOJQJ]^JaJ*"+"h)OJQJ^J,1h. A!"#$% DyK zlata.mestric@zg.t-com.hryK Zmailto:zlata.mestric@zg.t-com.hryX;H,]ą'c@@@ NormalCJ_HaJmHsHtHDA@D Default Paragraph FontRiR  Table Normal4 l4a (k(No Listjj \? Table Grid7:V0d@d Header,Zaglavlje prve stranice  p#6U@6  Hyperlink >*B*ph*[\]u000000000000K00K000\M-P H % !*"+" +" +" X[]"89ABsu}~  "$/1@BNP[]su|}  35@BMO^`lny{@HPR]uqu h hh^h`o(hH.88^8`OJQJ^Jo(hHo^`OJQJo(hH  ^ `OJQJo(hH  ^ `OJQJ^Jo(hHoxx^x`OJQJo(hHHH^H`OJQJo(hH^`OJQJ^Jo(hHo^`OJQJo(hHqu         Q0I_$f+ I_$CI_$\I_$h$I_$yZI_$hY / I_$/-Cq-I_$cu6ibBI_$n.Dcu68(FI_$mFygGhY .II_$5JJI_$o]lMI_$YMXI_$'g\I_$XX_I_$`I_$;d/ ;XiI_$dD}mFI_$+*vfE IG]$ 1$)^+"-61Y3)71<\?sK NeUh_Ujmf.sLEw|rwFz4 %Q^7Ax[JJcM{(65aqBU@\\$7\\4||``@``@@UnknownGz Times New Roman5Symbol3& z Arial?5 z Courier New;Wingdings"1d&e&e& $ $ !r4d 2qHX)?m2ZPOLYMORPHISMS IN TWO PARAOXONASE GENES- pon1 AND pon2 IN PATIENTS WITH PERIPHERAL STENOSISkardumZlata Flegar-Meatri Oh+'0 ,8H ht    \POLYMORPHISMS IN TWO PARAOXONASE GENES- pon1 AND pon2 IN PATIENTS WITH PERIPHERAL STENOSISkardumNormalZlata Flegar-Meštrić9Microsoft Office Word@~@^t@et@Yu$՜.+,D՜.+,H hp  'private  [POLYMORPHISMS IN TWO PARAOXONASE GENES- pon1 AND pon2 IN PATIENTS WITH PERIPHERAL STENOSIS Title 8@ _PID_HLINKSA|1]!mailto:zlata.mestric@zg.t-com.hrF  !"#$%&'(*+,-./02345678;Root Entry Fu=Data 1TableWordDocument.*SummaryInformation()DocumentSummaryInformation81CompObjq  FMicrosoft Office Word Document MSWordDocWord.Document.89q