Naslov
POLYMORPHISMS OF PARAOXONASE GENES AS A GENETIC RISK FACTOR IN PERIPHERAL ATHEROSCLEROSIS

Autori
Flegar-Meštrić, Zlata ; Kardum-Paro, Mirjana Mariana ; Perkov, Sonja ; Vidjak, Vinko ; Novačić, Karlo ; Grdić, Marija ; Juretić, Dubravka ; Barišić, Karmela

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
07IFCC – EFCC – EUROMEDLAB 2009 – Innsbruck, 7-11 June 2009, Clin Chem Lab Med 2009 ; 47, Special Supplement, pp S1 – S409, June 2009 / - , 2009, S304-S304

Skup
IFCC – EFCC – EUROMEDLAB 2009 – Innsbruck, 7-11 June 2009

Mjesto i datum
Innsbruck, Austrija, 07.06.2009. - 11.06.2009

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
polymorphisms of paraoxonase genes; peripheral atherosclerosis

Sažetak
Background. The most common polymorphisms in the coding (Q192R and L55M) and in the promoter region (-108C>T) of pon1 gene, as well as S311C polymorphism of pon2 gene, influence the enzyme anti-oxidant capacity and could be one of the genetic risk factors for the development of atherosclerosis. The aim of study was to examine the polymorphisms of pon1 and pon2 genes in patients with peripheral atherosclerosis. Methods. DNA was extracted from peripheral blood leukocytes (30 controls and 30 patients with peripheral atherosclerosis) and used for amplification by polymerase chain reaction (PCR) and restriction analysis. Differences in genotypes distribution were tested by Fischer′ s exact test or Chi square test. Results. Genotype frequencies of pon1 and pon2 genes polymorphisms founded in cases vs. controls were: 21 (0, 70) QQ, 9 (0, 30) QR, 0 (0, 00) RR vs. 15 (0, 50) QQ, 13 (0, 43) QR, 2 (0, 07) RR for Q192R ; 11 (0, 37) LL, 14 (0, 47) LM, 5 (0, 16) MM vs. 11 (0, 37) LL, 15 (0, 50) LM, 4 (0, 13) MM for L55M ; 0 (0, 00) CC, 15 (0, 50) CS, 15 (0, 50) SS vs. 1 (0, 04) CC, 13 (0, 43) CS, 16 (0, 53) SS for S311C and 16 (0, 55) CC, 5 (0, 17) CT, 8 (0, 28) TT vs. 11 (0, 37) CC, 17 (0, 57) CT, 2 (0, 06) TT for -108C>T. Conclusions. There was no significant difference in distribution of Q192R (p =0, 187), L55M (p = 0, 929) or S311C genotypes (p = 1, 000), but significant difference in distribution of -108C>T genotype (p = 0, 004) between patients with peripheral atherosclerosis and controls was found.

Izvorni jezik
Engleski

Znanstvena područja
Farmacija

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