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Pregled bibliografske jedinice broj: 404134

The association of platelet GPIbα 145Thr/Met (HPA-2a/2b) with myocardial infarction and coronary artery disease


Čuljak, Aleksić, Marlena; Mesarić, Jasna
The association of platelet GPIbα 145Thr/Met (HPA-2a/2b) with myocardial infarction and coronary artery disease // Journal of thrombosis and thrombolysis, 29 (2010), 3; 378-379 doi:10.1007/s11239-009-0358-7 (podatak o recenziji nije dostupan, pismo uredniku, znanstveni)


CROSBI ID: 404134 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
The association of platelet GPIbα 145Thr/Met (HPA-2a/2b) with myocardial infarction and coronary artery disease

Autori
Čuljak, Aleksić, Marlena ; Mesarić, Jasna

Izvornik
Journal of thrombosis and thrombolysis (0929-5305) 29 (2010), 3; 378-379

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pismo uredniku, znanstveni

Ključne riječi
platelet polymorphism ; myocardial infarction ; coronary artery disease

Sažetak
We aimed to investigate if the GPIbα 145Thr/Met (HPA-2a/2b) is associated with fatal pre- hospital myocardial infarction (MI) and coronary artery disease (CAD), aiming to find a genetic marker that could be used in the early (pre-clinical) disease diagnostics and possibly even disease prevention. A total of 402 cases of MI and CAD were included in the study (201 cases of CAD and 201 cases with both CAD and MI), supplemented with 202 controls (defined as the patients who underwent coronarography and had not been diagnosed with any of the two diagnoses). Genotyping was performed using PCR LightCycler  2 . The analysis was performed using Fisher's exact test, due to the small number of homozygous (Met/Met) cases. The results suggest that the prevalence of homozygous Met/Met was much higher in cases than controls, thus suggesting that it might be utilized as the disease prevention marker. The difference was significant (P=0.021). However, the application of the logistic regression model with age and gender as the additional covariates indicated the increasing trend of the risk among the GPIbα genotypes (Thr/Thr was used as the referent group, Thr/Met had an odds ratio of 1.18 [95% confidence intervals 0.76- 1.82], while Met/Met had an odds ratio of 3.01 [0.32-28.37] ; the difference was not significant ; P=0, 494).

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekti:
108-1081873-1890 - TRANSFUZIJSKO LIJEČENJE: RAZVOJ I PRIMJENA ZNANSTVENIH SPOZNAJA (Mesarić, Jasna, MZOS ) ( CroRIS)

Ustanove:
Medicinski fakultet, Zagreb,
Hrvatski zavod za transfuzijsku medicinu,
Sveučilište Libertas

Profili:

Avatar Url Jasna Mesarić (autor)

Poveznice na cjeloviti tekst rada:

doi www.springerlink.com

Citiraj ovu publikaciju:

Čuljak, Aleksić, Marlena; Mesarić, Jasna
The association of platelet GPIbα 145Thr/Met (HPA-2a/2b) with myocardial infarction and coronary artery disease // Journal of thrombosis and thrombolysis, 29 (2010), 3; 378-379 doi:10.1007/s11239-009-0358-7 (podatak o recenziji nije dostupan, pismo uredniku, znanstveni)
Čuljak, Aleksić, Marlena & Mesarić, J. (2010) The association of platelet GPIbα 145Thr/Met (HPA-2a/2b) with myocardial infarction and coronary artery disease. Journal of thrombosis and thrombolysis, 29 (3), 378-379 doi:10.1007/s11239-009-0358-7.
@article{article, author = {Mesari\'{c}, Jasna}, year = {2010}, pages = {378-379}, DOI = {10.1007/s11239-009-0358-7}, keywords = {platelet polymorphism, myocardial infarction, coronary artery disease}, journal = {Journal of thrombosis and thrombolysis}, doi = {10.1007/s11239-009-0358-7}, volume = {29}, number = {3}, issn = {0929-5305}, title = {The association of platelet GPIbα 145Thr/Met (HPA-2a/2b) with myocardial infarction and coronary artery disease}, keyword = {platelet polymorphism, myocardial infarction, coronary artery disease} }
@article{article, author = {Mesari\'{c}, Jasna}, year = {2010}, pages = {378-379}, DOI = {10.1007/s11239-009-0358-7}, keywords = {platelet polymorphism, myocardial infarction, coronary artery disease}, journal = {Journal of thrombosis and thrombolysis}, doi = {10.1007/s11239-009-0358-7}, volume = {29}, number = {3}, issn = {0929-5305}, title = {The association of platelet GPIbα 145Thr/Met (HPA-2a/2b) with myocardial infarction and coronary artery disease}, keyword = {platelet polymorphism, myocardial infarction, coronary artery disease} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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