Naslov
Genotoxic effects of anaesthetics in operating theatre personnel evaluated by the comet assay and micronucleus test

Autori
Rozgaj, Ružica ; Kašuba, Vilena ; Brozović, Gordana ; Jazbec, Anamarija

Izvornik
Intenational Journal of Hygiene and Environmental Health (1438-4639) 212 (2009), 1; 11-17

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
anaesthetics; occupational exposure; micronucleus test; comet assay

Sažetak
Genetic damage induced by anaesthetic gases in occupationally exposed populations was investigated using the comet assay and micronucleus test. The study included two groups of subjects: 50 operating theatre medical workers (anaesthesiologists, technicians and nurses) and 50 control subjects corresponding in sex, age and smoking habit. The exposed group revealed an increse in genome damage in both tests. In the comet assay, exposure to anaesthetics was a highly significant predictor of the tail length for technicians, while sex proved to be significant predictor of tail moment for women in exposed group. Micronucleus frequency increased significantly, showing threefold increase in exposed groups (RR>3.029). Univariate analysis showed significant influence of duration of exposure, while multivariate analysis showed age to be significant predictor of micronucleus frequency. The obtained results call for further, targeted investigation of exposure risk.

Izvorni jezik
Engleski

Znanstvena područja
Biologija

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