Pregled bibliografske jedinice broj: 402304
ROLE OF REGULATORY T LYMPHOCYTES AND NKT CELLS IN MODULATION OF INNATE IMMUNITY FOLOWING BURN INJURIES
ROLE OF REGULATORY T LYMPHOCYTES AND NKT CELLS IN MODULATION OF INNATE IMMUNITY FOLOWING BURN INJURIES // Zbornik radova Prvog kongresa hrvatskih alergologa i kliničkih imunologa s međunarodnim sudjelovanjem / Asja Stipić-Marković (ur.).
Zagreb: Hrvatsko društvo za alergologiju i kliničku imunologiju ; Hrvatski liječnički zbor, 2009. (poster, domaća recenzija, sažetak, znanstveni)
CROSBI ID: 402304 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
ROLE OF REGULATORY T LYMPHOCYTES AND NKT CELLS IN MODULATION OF INNATE IMMUNITY FOLOWING BURN INJURIES
Autori
Pirjavec-Mahic, A, ; Mrakovcic-Sutic, I,
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
Zbornik radova Prvog kongresa hrvatskih alergologa i kliničkih imunologa s međunarodnim sudjelovanjem
/ Asja Stipić-Marković - Zagreb : Hrvatsko društvo za alergologiju i kliničku imunologiju ; Hrvatski liječnički zbor, 2009
Skup
Prvi kongres hrvatskih alergologa i kliničkih imunologa s međunarodnim sudjelovanjem
Mjesto i datum
Zagreb, Hrvatska, 21.05.2009. - 23.05.2009
Vrsta sudjelovanja
Poster
Vrsta recenzije
Domaća recenzija
Ključne riječi
burns; innate immune response; NKT cells; Tregs
Sažetak
Imbalanced innate immunity can be a springboard for the development of various pathological conditions: tumor, autoimmune diseases, hypersensitivity as well as slower, hindered or incomplete healing, or lethal outcome during other illnesses. Regulatory T cells (Tregs) and NKT cells, as carries of innate immunity play a key role in the control of pathological immune responses. Mature dendritic cells stimulate the expression of Tregs. Treg cells exprimise perforin and granzyme, but the functional importance of this pathway is still not completely defined. NKT cells regulate antitumor, autoimmune, allergic and antimicrobial immunological response. The aim of the study: Our hypothesis about regulatory network of Treg and NKT cells, were studied on the severe change of natural immunity: on burns as example of local and systemic injuries. Results: Functional changes in regulatory T and NKT cells correlate with clinical stages, prognosis of illnesses and success of treatment of burned patients. Tne number of Trges and NKT cells was significantly decreased in patients with burn injuries and is comparable with the level of the disorders. Conclusion: These Tregs and NKT monitoring may contribute to a better treatment of patients suffering from burn injuries and pain, contributing to faster recovery and/or reducing infections in all conditions characterized by impaired organism resistance. Acknowledgment: This work was supported by grant from the Croatian Ministry of Science (project 0620096-0094).
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti
POVEZANOST RADA
Projekti:
062-0620096-0094 - Regulacijske T i NKT stanice u kontroli tumorskog rasta, opeklina i autoimunosti (Mrakovčić-Šutić, Ines, MZOS ) ( CroRIS)
Ustanove:
Medicinski fakultet, Rijeka
