Naslov
Involvement of p16 and PTCH in pathogenesis of melanoma and basal cell carcinoma

Autori
Čretnik, Maja ; Poje, Gorazd ; Musani, Vesna ; Krušlin, Božo ; Ozretić, Petar ; Tomas, Davor ; Šitum, Mirna ; Levanat, Sonja

Izvornik
International journal of oncology (1019-6439) 34 (2009), 4; 1045-1050

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
p16 ; PTCH ; melanoma ; basal cell carcinoma ; signaling pathways

Sažetak
The involvement of two tumor suppressors p16 and Ptch in pathogenesis of cutaneous melanomas and basal cell carcinomas (BCCs) was studied through expression of Ptch and p16 and genetic alterations in 9p21 region (p16) and in 9q22.3 region (PTCH) of chromosome 9. Immunohistochemical analyses of paraffin-embedded tissues with Ptch and p16 antibodies, typing for 9q22-q31 and 9p21 region with polymorphic markers and p16 and Ptch mutation detection was done. Higher expression of p16 and Ptch in melanoma and BCC of the skin was frequently detected in studied cases. However, allelic loss of PTCH region occurs more frequently in BCCs than loss of heterozygosity of p16 region. Both types of tumors, BCCs and melanomas, suggest involvement of Hh-Gli signaling pathway, but using different mechanisms.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA