Pregled bibliografske jedinice broj: 401214
The effect of drotaverine hydrochloride in acute colicky pain caused by renal and ureteric stones
The effect of drotaverine hydrochloride in acute colicky pain caused by renal and ureteric stones // British journal of urology international, 92 (2003), 1; 92-96 doi:10.1046/j.1464-410X.2003.04262.x (međunarodna recenzija, članak, znanstveni)
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Naslov
The effect of drotaverine hydrochloride in acute colicky pain caused by renal and ureteric stones
Autori
Romics, I. ; Molnar, D.L. ; Timberg, G. ; Jelaković, Bojan ; Koszsegis, G. ; Blasko, G.
Izvornik
British journal of urology international (1464-4096) 92
(2003), 1;
92-96
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
reteric stones; pain; drotaverine hydrochloride; spasmolytic treatment; renal colic
(ureteric stones; pain; drotaverine hydrochloride; spasmolytic treatment; renal colic)
Sažetak
To assess the spasmolytic effect ofdrotaverine hydrochloride in colicky paincaused by renal and ureteric stones. In a placebo-controlled, multicentre, multinational, randomized, double-blind study changes in the intensity of pain were recorded using a visual analogue scale (VAS), a four-grade (five points) pain intensity (PI) scale and a pain-relief scale. The primary endpoint was the evaluation of the antispasmodic effect of drotaverine during a 3-h study period, to confirm that drotaverine abolished or significantly decreased the intensity of pain in renal colic. The painkilling effect was defined as a decrease by at least half in the PI scale, and/or a ≥ 40% decrease in the VAS 40 min after either the first or the second injection of 80 mg drotaverine or placebo (if necessary the dose could be repeated once). In all, 140 patients were enrolled but 38 withdrew, leaving 102 patients for analysis (48 drotaverine, 54 placebo ; mean age 42.5 years, SD 11.25, and 41.7, SD 10.79). Drotaverine was effective in 79% of patients and placebo in only 46% (P < 0.001). There were no serious adverse effects. There were 20 minor side-effects in the drotaverine and four in the placebo group ; none of the patients required treatment. The most frequent sideeffects were a transitory decrease in blood pressure, vertigo, nausea or vomiting. Intravenous drotaverine provides effective pain relief in more than two-thirds of patients with renal colic, with no serious side-effects.
Izvorni jezik
Engleski
Znanstvena područja
Kliničke medicinske znanosti
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- SCI-EXP, SSCI i/ili A&HCI
