Naslov
Synthesis and Biotransformations of Quaternary Quinuclidine Compounds

Autori
Primožič, Ines ; Baumann, Krešimir ; Tomić, Srđanka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
XXI. hrvatski skup kemičara i kemijskih inženjera : knjiga sažetaka / Novak, Predrag - Zagreb : Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI), 2009, 29-29

ISBN
978-953-6894-38-3

Skup
XXI. hrvatski skup kemičara i kemijskih inženjera

Mjesto i datum
Trogir, Hrvatska, 19.04.2009. - 22.04.2009

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Nije recenziran

Ključne riječi
butyrylcholinesterase ; quinuclidinium derivatives ; kinetic study ; resolution of enantiomers

Sažetak
Optically active quinuclidines are parts of several alkaloids and important intermediates in the preparation of pharmacologically active compounds. Therefore, interactions with various biomolecules as well as methods for the efficient production of chiral quinuclidines are examined. It has been shown that stereoselectivity of hydrolyses catalysed by butyrylcholinesterase (BChE ; EC 3.1.1.8) was in favour of the (R)-enantiomers in the case of quinuclidinium esters and amides.1-5 In order to further investigate structure-activity relationship of enyzme and quinuclidine esters and amides, several different racemic and enantiomerically pure quinuclidium derivatives were synthesized. All compounds were then tested as substrates and/or inhibitors of a horse serum butyrylcholinesterase. Dependence of butyrylcholinesterase activity and enantioselectivity on the substrate's acyl structure, preference of butyrylcholinesterase towards (R)-enantiomers and the differences in the rates of hydrolysis depending on the quaternary ammonium and acyl group will be discussed.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

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