Naslov
Antimicrobial resistance of H. pylori to the outcome of 10-days vs 7-days moxifloxacin based therapy for eradication

Autori
Bago, Josip ; Belošić Halle, Željka ; Troskot Perić, Rosana ; Marušić, Marinko ; Bakula, Vinko ; Kučušec, Nastja ; Pevec, Branko ; Majstorović, Karolina

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts of the British Society of Gastroenterology Annual General Meeting 2008 ; u: Gut. 40 (2008) (S1) 1-428 / - , 2008, A327-A327

Skup
British Society of Gastroenterology Annual General Meeting

Mjesto i datum
Birmingham, Ujedinjeno Kraljevstvo, 10.03.2008. - 13.03.2008

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
H. pylori; resistance; moxifloxacin

Sažetak
Antibiotic resistance decreses success of H. pylori eradication. Recently published results show a low rate of resistance and better compliance with moxifloxacin based regiments. Wherher 7 days moxifloxacine with lansoprasole and amoxycillin can be compared with 10 days moxifloxacine with lansoprasole and amoxycillin according to moxifloxacin resistance. Patients with non-ulcer dyspepsia and culture and histology positive H. pylori infection and (n=150)were randomly assigned into two groups. The first group (n=75) receive moxifloxacin 400 mg/d during 7 days and the other group (n=75) received moxifloxacin 400 mg/d during 10 days. All patients receive amoxycillin 1 g twice daily, lansoprasole 30 mg twice dailiy during 7 days. All H. pylori cultures were tested for sensitivity to moxifloxacin. 138 patients (92%) completed the study, 68 in the first group and 70 in the second. Eradicetion rates were, in the 7 days moxifloxacin group, 87%(57/68) and 90% in the second (63/70) according to the PP analysis ; p=n.s. Among 129 patients (86% of entire study group), 6% of strains were primary resistant to moxifloxacin. Eradication of moxifloxacin sensitive/resistant strains was 98%/66%, p<0.05 Antimicrobial resistance decreases the sucess of eradication. Concerning low moxifloxacine resistance, moxifloxacin based therapy for H. pylori eradication is promising to achieve the favourable eradication rate.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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