Naslov
Alterations in some blood coagulation parameters in naturally occurring cases of canine babesiosis

Autori
Barić Rafaj, Renata ; Matijatko, Vesna ; Kiš, Ivana ; Kučer, Nada ; Živičnjak, Tatjana ; Lemo, Nikša ; Žvorc, Zdravko ; Brkljačić, Mirna ; Mrljak, Vladimir

Izvornik
Acta veterinaria Hungarica (0236-6290) 57 (2009), 2; 295-304

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
dog; Babesia canis; hemostasis; coagulation

Sažetak
We examined changes in coagulation parameters in dogs naturally infected (n=30) with Babesia canis canis and hemostasis was evaluated and compared to values obtained from healthy dogs (n=29). To date, there have not been any studies examining the dynamics of thrombin-antithrombin complex formation in cases of canine babesiosis. Coagulation parameters evaluated before (day 0) and on days 1, 2, and 3 after treatment with imidocarb (6 mg/kg inj. s/c) included determining platelet counts, the formation of thrombin-antithrombin complexes (TAT), prothrombin time (PT), activated partial thromboplastin time (APTT) and antithrombin III (AT III) activity. TAT complexes were significantly elevated in animals with babesiosis on days 0 and 2 (mean 49.7 and 87.7 µ ; g/L vs. control, 7.2 µ ; g/L). AT III activity was significantly decreased at all time points examined. There were no differences in PT. On days 2 and 3 the APTT was significantly shortened in the infected dogs when compared to control animals (means of 21.3 and 19.2 s compared to control, 30.0 s). Our analysis demonstrated that infected dogs had significant thrombocytopenia during the course of the study (mean day 0 - 29x109/L, day 1 - 48x109/L, day 2 - 47x109/L and day 3 - 87 x109/L, vs. control - 259 x109/L). These data suggested that babesiosis in dogs compromises primary and secondary hemostasis and that induction of disseminated intravascular coagulation (DIC) occurs in canine babesiosis.

Izvorni jezik
Engleski

Znanstvena područja
Veterinarska medicina

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