Naslov
Genetic polymorphisms of thiopurine methyltransferase in Croatian inflammatory bowel disease patients

Autori
Ladić, A ; Čuković Čavka, S ; Božina, N ; Krznarić, Ž ; Sertić, J ; Vucelić, B

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
Journal of Crohn's and Colitis / - , 2009, 114-114

Skup
4th Congress of ECCO

Mjesto i datum
Hamburg, Njemačka, 05.02.2009. - 07.02.2009

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
thiopurine methyltransferase; inflammatory bowel disease

Sažetak
Thiopurines are important drugs used in the treatment of steroid-dependent and refractory inflammatory bowel disease. They exhibit their activity once they are metabolized via methylation by thiopurine methyltransferase (TPMT) enzyme. TPMT displays a range of activity due to genetic polymorphism meaning that frequency of certain TPMT alleles determines interindividual variations. Therefore the likelihood of adverse effect and interindividual differences in therapeutic efficacy may relate to thiopurine TPMT genotype. It was established in some studies that TPMT testing should be introduced prior to the initiation of thiopurines in therapy. Regarding to different frequences of TPMT alleles reported from different populations the aim of this study was to evaluate the frequency of the most common TPMT variants in our IBD patients. No reports on the prevalence of TPMT polymorphisms in Croatian population have been published.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA